Protein Alignment 5-HT7 and Adrb3

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_008769537.1
• Gene: Adrb3 / 25645
• RGDID: 2061
• Length: 421
• Species: Rattus norvegicus
• Alignment Length: 413
• Identity: 143/413 - (34%)
• Similarity: 192/413 - (46%)
• Gaps: 80/413 - (19%)

  Fly   134 NTTLVPLSDTPLLLEEFAAGEFVLP--PLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRP 196
            |.:|...||.| .|:..||....||  |..:.....:|   .|.||.||:||..|:....:|:..
  Rat    29 NGSLAFWSDAP-TLDPSAANTSGLPGVPWAAALAGALL---ALATVGGNLLVITAIARTPRLQTI 89

  Fly   197 CNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRY 261
            .|..:.|||.:||.|.|||||......:...|..|...|::|.|.||||.||||..|||::||||
  Rat    90 TNVFVTSLATADLVVGLLVMPPGATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRY 154

  Fly   262 LAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLI----LGNEHEDEE--GQP-ICTVCQN 319
            ||:|.||.||...|.||....|.:||:.:|.:|..|::.    :|.:.|.:|  ..| .|:...|
  Rat   155 LAVTNPLRYGTLVTKRRARAAVVLVWIVSATVSFAPIMSQWWRVGADAEAQECHSNPRCCSFASN 219

  Fly   320 FAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEEKRAQTHLQQAL------NGTGSPSAPQA 378
            ..|.:.::..|||:||.||||||.::|..|       ||.:..|::.|      ....|||...:
  Rat   220 MPYALLSSSVSFYLPLLVMLFVYARVFVVA-------KRQRRLLRRELGRFPPEESPRSPSRSPS 277

  Fly   379 PPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLR 443
            |....|..||.|              ..:||                  .....||....|:.||
  Rat   278 PATVGTPTASDG--------------VPSCG------------------RRPARLLPLGEHRALR 310

  Fly   444 FQLAKEKKASTTLGIIMSAFTVCWLPFFIL----ALIRPFETMHVPASLSSLFLWLGYANSLLNP 504
                       |||:||..|::||||||:.    ||:.|   ..||:.:.....|||||||..||
  Rat   311 -----------TLGLIMGIFSLCWLPFFLANVLRALVGP---SLVPSGVFIALNWLGYANSAFNP 361

  Fly   505 IIYATLNRDFRKPFQEILYFRCS 527
            :||.. :.|||..|:.:|   ||
  Rat   362 LIYCR-SPDFRDAFRRLL---CS 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	128/371 (35%)
		TM helix 1	164..190	CDD:320452	9/25 (36%)
		TM helix 2	197..223	CDD:320452	12/25 (48%)
		TM helix 3	235..265	CDD:320452	20/29 (69%)
		TM helix 4	277..299	CDD:320452	8/21 (38%)
		TM helix 5	319..348	CDD:320452	14/28 (50%)
		TM helix 6	447..477	CDD:320452	14/33 (42%)
		TM helix 7	486..511	CDD:320452	11/24 (46%)
Adrb3	XP_008769537.1	7tm_GPCRs	69..374	CDD:475119	126/358 (35%)
		TM helix 2	91..113	CDD:410628	12/21 (57%)
		TM helix 3	129..151	CDD:410628	13/21 (62%)
		TM helix 4	174..190	CDD:410628	5/15 (33%)
		TM helix 5	220..243	CDD:410628	11/22 (50%)
		TM helix 6	309..331	CDD:410628	14/32 (44%)
		TM helix 7	343..368	CDD:410628	11/25 (44%)