Protein Alignment 5-HT7 and Hrh2

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001399940.1
• Gene: Hrh2 / 25461
• RGDID: 2831
• Length: 402
• Species: Rattus norvegicus
• Alignment Length: 412
• Identity: 128/412 - (31%)
• Similarity: 192/412 - (46%)
• Gaps: 101/412 - (24%)

  Fly   163 IFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEK 227
            :.:|:||..:||.|:.|||:||:||.:.|:||...|..:||||.:||.:.|||:|.:.:|::..|
  Rat    19 VTISVVLTTLILITIAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVLPFSAIYQLSFK 83

  Fly   228 WNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAAC 292
            |:||.:.|:|:.|.||:.||||||||..||:|||.|:|.||.|.|..||.|:.:.:..:|:.:..
  Rat    84 WSFGHVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISIT 148

  Fly   293 ISLPPLLILGNEHEDEEGQP---ICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVL 354
            :|...:.:..|......|..   .|.|..|..|.:...|.:||:||.:|...||:||:.||.
  Rat   149 LSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGLVTFYLPLLIMCVTYYRIFKIARE--- 210

  Fly   355 EEKRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALA 419
                                  ||..:.|                           :||...|
  Rat   211 ----------------------QAKRINH---------------------------ISSWKAA-- 224

  Fly   420 GHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPFE-TMH 483
                                      ..:|.||:.||..:|.||.:||.|:|...:.|... ...
  Rat   225 --------------------------TIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDA 263

  Fly   484 VPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRCSSLN---------------TMM 533
            :..::..:.||||||||.||||:||.||||||..:|::.:.:.:|.|               :..
  Rat   264 INEAVEGIVLWLGYANSALNPILYAALNRDFRTAYQQLFHCKFASHNSHKTSLRLNNSLLPRSQS 328

  Fly   534 RENYYQDQYGEPPSQRVMLGDE 555
            ||..:|::  :|...:|..|.|
  Rat   329 REGRWQEE--KPLKLQVWSGTE 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	118/358 (33%)
		TM helix 1	164..190	CDD:320452	13/25 (52%)
		TM helix 2	197..223	CDD:320452	11/25 (44%)
		TM helix 3	235..265	CDD:320452	19/29 (66%)
		TM helix 4	277..299	CDD:320452	3/21 (14%)
		TM helix 5	319..348	CDD:320452	12/28 (43%)
		TM helix 6	447..477	CDD:320452	12/29 (41%)
		TM helix 7	486..511	CDD:320452	14/24 (58%)
Hrh2	NP_001399940.1	7tmA_Histamine_H2R	19..298	CDD:320179	118/358 (33%)
		TM helix 1	20..46	CDD:320179	13/25 (52%)
		TM helix 2	53..80	CDD:320179	12/26 (46%)
		TM helix 3	91..121	CDD:320179	19/29 (66%)
		TM helix 4	133..153	CDD:320179	3/19 (16%)
		TM helix 5	178..208	CDD:320179	12/29 (41%)
		TM helix 6	226..256	CDD:320179	12/29 (41%)
		TM helix 7	266..291	CDD:320179	14/24 (58%)