DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 5-HT7 and Hrh2

DIOPT Version :9

Sequence 1:	NP_001263131.1	Gene:	5-HT7 / 43669	FlyBaseID:	FBgn0004573	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_008769708.1	Gene:	Hrh2 / 25461	RGDID:	2831	Length:	413	Species:	Rattus norvegicus

Alignment Length:	412	Identity:	128/412 - (31%)
Similarity:	192/412 - (46%)	Gaps:	101/412 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 IFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEK 227
            :.:|:||..:||.|:.|||:||:||.:.|:||...|..:||||.:||.:.|||:|.:.:|::..|
  Rat    19 VTISVVLTTLILITIAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVLPFSAIYQLSFK 83

  Fly   228 WNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAAC 292
            |:||.:.|:|:.|.||:.||||||||..||:|||.|:|.||.|.|..||.|:.:.:..:|:.:..
  Rat    84 WSFGHVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISIT 148

  Fly   293 ISLPPLLILGNEHEDEEGQP---ICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVL 354
            :|...:.:..|......|..   .|.|..|..|.:...|.:||:||.:|...||:||:.||.
  Rat   149 LSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGLVTFYLPLLIMCVTYYRIFKIARE--- 210

  Fly   355 EEKRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALA 419
                                  ||..:.|                           :||...|
  Rat   211 ----------------------QAKRINH---------------------------ISSWKAA-- 224

  Fly   420 GHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPFE-TMH 483
                                      ..:|.||:.||..:|.||.:||.|:|...:.|... ...
  Rat   225 --------------------------TIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDA 263

  Fly   484 VPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRCSSLN---------------TMM 533
            :..::..:.||||||||.||||:||.||||||..:|::.:.:.:|.|               :..
  Rat   264 INEAVEGIVLWLGYANSALNPILYAALNRDFRTAYQQLFHCKFASHNSHKTSLRLNNSLLPRSQS 328

  Fly   534 RENYYQDQYGEPPSQRVMLGDE 555
            ||..:|::  :|...:|..|.|
  Rat   329 REGRWQEE--KPLKLQVWSGTE 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_001263131.1	7tm_4	173..>342	CDD:304433	70/171 (41%)
5-HT7	NP_001263131.1	7tm_1	179..507	CDD:278431	104/331 (31%)
Hrh2	XP_008769708.1	7tm_4	29..302	CDD:304433	116/352 (33%)
Hrh2	XP_008769708.1	7tm_1	35..287	CDD:278431	104/331 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910