Protein Alignment 5-HT7 and Drd4

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_006230583.1
• Gene: Drd4 / 25432
• RGDID: 2522
• Length: 389
• Species: Rattus norvegicus
• Alignment Length: 470
• Identity: 144/470 - (30%)
• Similarity: 209/470 - (44%)
• Gaps: 106/470 - (22%)

  Fly    82 IASASSTGSG---SGSGS---GSGSGSGSGSYGLASMNSSPIAIVSYQGITSSNLGDSNTTLVPL 140
            :.::|:||.|   :|.|.   |:|:|.|....|.|::
  Rat     1 MGNSSATGDGGLLAGRGPESLGTGTGLGGAGAGAAAL---------------------------- 37

  Fly   141 SDTPLLLEEFAAGEFVLPPLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLA 205
                                    |..||||.::  :.||.|||::|...|.|:.|.||.:||||
  Rat    38 ------------------------VGGVLLIGMV--LAGNSLVCVSVASERILQTPTNYFIVSLA 76

  Fly   206 LSDLCVALLVMPMALLYEVL-EKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLE 269
            .:||.:|:||:|:.:..||. ..|...|.|||..::.||:.|||||.|||||||||::|:|.||.
  Rat    77 AADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLR 141

  Fly   270 YGVKRTPRRMMLCVGIVWLAAACISLPPLLILGNEHEDEEGQ-PICTVC--QNFAYQIYATLGSF 331
            |  .:..:..:|.:...||.:|.::.|.:..|    .|..|: |  |||  ::..|.:|:::.||
  Rat   142 Y--NQQGQCQLLLIAATWLLSAAVAAPVVCGL----NDVPGRDP--TVCCLEDRDYVVYSSICSF 198

  Fly   332 YIPLSVMLFVYYQIFRAARRIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHTE----------L 386
            ::|..:||.:|:..||..||     ..|..|.:........||.|..|....|:          .
  Rat   199 FLPCPLMLLLYWATFRGLRR-----WEAARHTKLHSRAPRRPSGPGPPVSDPTQGPLFSDCPPPS 258

  Fly   387 ASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAK--- 448
            .|.......||...:.|:.|.|              |.|.:.....|...|.....|.:.||
  Rat   259 PSLRTSPTVSSRPESDLSQSPC--------------SPGCLLPDAALAQPPAPSSRRKRGAKITG 309

  Fly   449 -EKKASTTLGIIMSAFTVCWLPFFILALIRPF-ETMHVPASLSSLFLWLGYANSLLNPIIYATLN 511
             |:||...|.:::.||.:||.|||::.:.|.. ....|...|.|...||||.||.||||||...|
  Rat   310 RERKAMRVLPVVVGAFLMCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFN 374

  Fly   512 RDFRKPFQEILYFRC 526
            .:||..|::.|..||
  Rat   375 AEFRSVFRKTLRLRC 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	128/373 (34%)
		TM helix 1	164..190	CDD:320452	11/25 (44%)
		TM helix 2	197..223	CDD:320452	12/25 (48%)
		TM helix 3	235..265	CDD:320452	19/29 (66%)
		TM helix 4	277..299	CDD:320452	5/21 (24%)
		TM helix 5	319..348	CDD:320452	9/28 (32%)
		TM helix 6	447..477	CDD:320452	13/33 (39%)
		TM helix 7	486..511	CDD:320452	14/24 (58%)
Drd4	XP_006230583.1	7tm_GPCRs	44..381	CDD:475119	124/365 (34%)
		TM helix 2	69..91	CDD:410628	12/21 (57%)
		TM helix 3	108..130	CDD:410628	13/21 (62%)
		TM helix 4	151..167	CDD:410628	4/15 (27%)
		TM helix 5	187..210	CDD:410628	7/22 (32%)
		TM helix 6	315..337	CDD:410628	8/21 (38%)
		TM helix 7	349..374	CDD:410628	14/24 (58%)