DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 5-HT7 and Htr1d

DIOPT Version :9

Sequence 1:	NP_001263131.1	Gene:	5-HT7 / 43669	FlyBaseID:	FBgn0004573	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_036984.1	Gene:	Htr1d / 25323	RGDID:	2847	Length:	374	Species:	Rattus norvegicus

Alignment Length:	375	Identity:	139/375 - (37%)
Similarity:	205/375 - (54%)	Gaps:	45/375 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 IFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEK 227
            |.:.:||.|:.|.||:.|..|...:.:.:||..|.|||:.|||.:||.|::||||:::.|.....
  Rat    36 ISLVVVLSIITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRT 100

  Fly   228 WNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAAC 292
            ||||.:|||||||.|:.|||||||:||.|::|||.|||..|||..:||.......:..||..:.|
  Rat   101 WNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWAISIC 165

  Fly   293 ISLPPLL-ILGNEHEDEEGQPICTV-CQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLE 355
            ||:|||. .....||:...   |.| ....:|.||:|.|:||||..:::.:|.:|:.|||..:|.
  Rat   166 ISIPPLFWRQATAHEEMSD---CLVNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRILN 227

  Fly   356 E-----KRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSSGG 415
            .     ||..|  .|.:.|:...|.....|..|         :.|:....:.|.::..
  Rat   228 PPSLYGKRFTT--AQLITGSAGSSLCSLNPSLH---------ESHTHTVGSPLFFNQV------- 274

  Fly   416 GALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPF- 479
                      .:..:..:|     ::.|...|:|:||:.|||||:.||.:||||||:::|:.|.
  Rat   275 ----------KIKLADSIL-----ERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPIC 324

  Fly   480 -ETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRCSS 528
             ::..:..:|...|.||||.|||:||:||...|.|||:.||.:::||.:|
  Rat   325 RDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQRVVHFRKAS 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_001263131.1	7tm_4	173..>342	CDD:304433	76/170 (45%)
5-HT7	NP_001263131.1	7tm_1	179..507	CDD:278431	121/336 (36%)
Htr1d	NP_036984.1	7tmA_5-HT1B_1D	32..364	CDD:320455	134/363 (37%)
		TM helix 1	38..62	CDD:320455	8/23 (35%)
		TM helix 2	71..93	CDD:320455	13/21 (62%)
		TM helix 3	109..131	CDD:320455	16/21 (76%)
		Agonist binding. /evidence=ECO:0000250	111..120		5/8 (63%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250	132..134		1/1 (100%)
		TM helix 4	154..170	CDD:320455	5/15 (33%)
		TM helix 5	192..215	CDD:320455	9/22 (41%)
		TM helix 6	297..319	CDD:320455	13/21 (62%)
		Agonist binding. /evidence=ECO:0000250	311..315		3/3 (100%)
		TM helix 7	332..357	CDD:320455	13/24 (54%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250	349..353		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44443
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.870