DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 5-HT7 and Htr1b

DIOPT Version :9

Sequence 1:	NP_001263131.1	Gene:	5-HT7 / 43669	FlyBaseID:	FBgn0004573	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_071561.1	Gene:	Htr1b / 25075	RGDID:	2846	Length:	386	Species:	Rattus norvegicus

Alignment Length:	419	Identity:	141/419 - (33%)
Similarity:	222/419 - (52%)	Gaps:	72/419 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 SNTTLVPLSDTPLLLEEFAAGEFV------LPPLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVR 191
            ::.|.|||::   |....:|.:::      ||  ..:.:..:|.::.|.|.:.|..|...|...|
  Rat    15 TSQTGVPLAN---LSHNCSADDYIYQDSIALP--WKVLLVALLALITLATTLSNAFVIATVYRTR 74

  Fly   192 KLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAI 256
            ||..|.|||:.|||::||.|::||||::.:|.|..:|..|.::||.|:|.|:.||||||::||.|
  Rat    75 KLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVI 139

  Fly   257 SVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLILGNEHEDEEGQPICTV-CQNF 320
            ::|||.|||..::|..||||:|..:.:.:||:.:..|||||  ....:.:.||....|.| ..:.
  Rat   140 ALDRYWAITDAVDYSAKRTPKRAAIMIVLVWVFSISISLPP--FFWRQAKAEEEVLDCFVNTDHV 202

  Fly   321 AYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEEKRAQT--HLQQALNGTGSPSAPQAPPLGH 383
            .|.:|:|:|:||:|..:::.:|.:|:..||..:|::...:|  .|.:|...|.||        |.
  Rat   203 LYTVYSTVGAFYLPTLLLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSP--------GS 259

  Fly   384 TELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHH--------- 439
            |...:|.| .|...|.:.|                                |||.:
  Rat   260 TSSVTSIN-SRVPEVPSES--------------------------------GSPVYVNQVKVRVS 291

  Fly   440 ----KKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPF--ETMHVPASLSSLFLWLGYA 498
                :|.:...|:|:||:.|||||:.||.||||||||::|:.|.  :......::...|.||||.
  Rat   292 DALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLGYL 356

  Fly   499 NSLLNPIIYATLNRDFRKPFQEILYFRCS 527
            |||:|||||...|.||::.|.:::.|:|:
  Rat   357 NSLINPIIYTMSNEDFKQAFHKLIRFKCT 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_001263131.1	7tm_4	173..>342	CDD:304433	70/169 (41%)
5-HT7	NP_001263131.1	7tm_1	179..507	CDD:278431	122/345 (35%)
Htr1b	NP_071561.1	7tmA_5-HT1B_1D	42..376	CDD:320455	132/378 (35%)
		TM helix 1	48..72	CDD:320455	6/23 (26%)
		TM helix 2	81..103	CDD:320455	13/21 (62%)
		TM helix 3	119..141	CDD:320455	13/21 (62%)
		Agonist binding. /evidence=ECO:0000250	121..130		4/8 (50%)
		DRY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250	142..144		1/1 (100%)
		TM helix 4	164..180	CDD:320455	5/15 (33%)
		TM helix 5	202..225	CDD:320455	7/22 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..276		8/29 (28%)
		TM helix 6	309..331	CDD:320455	15/21 (71%)
		Agonist binding. /evidence=ECO:0000250	323..327		3/3 (100%)
		TM helix 7	344..369	CDD:320455	13/24 (54%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250	361..365		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44443
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.870