DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT7 and Adrb1

DIOPT Version :10

Sequence 1:NP_524599.1 Gene:5-HT7 / 43669 FlyBaseID:FBgn0004573 Length:564 Species:Drosophila melanogaster
Sequence 2:NP_036833.2 Gene:Adrb1 / 24925 RGDID:2059 Length:466 Species:Rattus norvegicus


Alignment Length:469 Identity:152/469 - (32%)
Similarity:219/469 - (46%) Gaps:82/469 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   103 GSGSYGLASMNSSPIAIVSYQGITSSNLGDSNTT---LVPLSDTPL-LLEEFAAGEFVLPPLTSI 163
            |:|:..|.:  |.|..:.|     ::.|.|...|   |:.|:..|. ||...:.|...|....:.
  Rat     2 GAGALALGA--SEPCNLSS-----AAPLPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTA 59

  Fly   164 FVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKW 228
            .:.::|.:::|..|||||||.:|:....:|:...|..::|||.:||.:.|||:|......|..:|
  Rat    60 GMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRW 124

  Fly   229 NFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACI 293
            .:|...|::|.|.||||.||||..||.|::|||||||.|..|....|..|....|..||..:|.:
  Rat   125 EYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARALVCTVWAISALV 189

  Fly   294 SLPPLLILGNEHEDEEGQ------PICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRI 352
            |..|:|:.....|.:|.:      ..|....|.||.|.:::.|||:||.:|.|||.::||.|::.
  Rat   190 SFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQ 254

  Fly   353 VLEEKRAQTHLQQALNGTGSPSAP-----QAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLS 412
            |   |:..:..::.|:|...|.:|     ..||.....||:..:.:|..|               
  Rat   255 V---KKIDSCERRFLSGPPRPPSPAPSPSPGPPRPADSLANGRSSKRRPS--------------- 301

  Fly   413 SGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIR 477
                                          |....:|:||..||||||..||:||||||:..:::
  Rat   302 ------------------------------RLVALREQKALKTLGIIMGVFTLCWLPFFLANVVK 336

  Fly   478 PFETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRCSSLNTMMRENYYQD-- 540
            .|....||..|...|.|||||||..|||||.. :.||||.||.:|.  |:......|...:.|  
  Rat   337 AFHRDLVPDRLFVFFNWLGYANSAFNPIIYCR-SPDFRKAFQRLLC--CARRAACRRRAAHGDRP 398

  Fly   541 -------QYGEPPS 547
                   :.|.|||
  Rat   399 RASGCLARAGPPPS 412

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT7NP_524599.1 7tmA_5-HT7 163..518 CDD:320452 126/365 (35%)
TM helix 1 164..190 CDD:320452 10/25 (40%)
TM helix 2 197..223 CDD:320452 10/25 (40%)
TM helix 3 235..265 CDD:320452 19/29 (66%)
TM helix 4 277..299 CDD:320452 7/21 (33%)
TM helix 5 319..348 CDD:320452 14/28 (50%)
TM helix 6 447..477 CDD:320452 17/29 (59%)
TM helix 7 486..511 CDD:320452 14/24 (58%)
Adrb1NP_036833.2 7tmA_Beta1_AR 59..376 CDD:320624 126/365 (35%)
TM helix 1 60..86 CDD:320624 10/25 (40%)
TM helix 2 93..120 CDD:320624 10/26 (38%)
TM helix 3 131..161 CDD:320624 19/29 (66%)
TM helix 4 175..193 CDD:320624 5/17 (29%)
TM helix 5 221..253 CDD:320624 16/31 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 264..302 10/82 (12%)
TM helix 6 306..336 CDD:320624 17/29 (59%)
TM helix 7 345..370 CDD:320624 14/25 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 398..466 4/15 (27%)
PDZ-Binding. /evidence=ECO:0000250 463..466
Blue background indicates that the domain is not in the aligned region.

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