DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 5-HT7 and Htr1a

DIOPT Version :9

Sequence 1:	NP_001263131.1	Gene:	5-HT7 / 43669	FlyBaseID:	FBgn0004573	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_036717.1	Gene:	Htr1a / 24473	RGDID:	2845	Length:	422	Species:	Rattus norvegicus

Alignment Length:	426	Identity:	172/426 - (40%)
Similarity:	239/426 - (56%)	Gaps:	58/426 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 SDTPLLLEEFAAGEFVLPPLTSI----FVSIVLLIVILGT-----VVGNVLVCIAVCMVRKLRRP 196
            ::|....|.|..|..|    |||    |...|:..::|||     |:||..|..|:.:.|.|:..
  Rat    10 NNTTASQEPFGTGGNV----TSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNV 70

  Fly   197 CNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRY 261
            .|||:.|||::||.|::||:|||.||:||.||..|.:.||::::.||||||:|||:||||::|||
  Rat    71 ANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRY 135

  Fly   262 LAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLILG-NEHEDEEGQPICTVCQNFAYQIY 325
            .|||.|::|..||||||....:.:.||....||:||:  || ...||......||:.::..|.||
  Rat   136 WAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPM--LGWRTPEDRSDPDACTISKDHGYTIY 198

  Fly   326 ATLGSFYIPLSVMLFVYYQIFRAAR-RI-----VLEEKRAQTHLQQALNGTGSPSAPQAPPLGHT 384
            :|.|:|||||.:||.:|.:|||||| ||     .:|:|.|.|.|     ||.|     |||...:
  Rat   199 STFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSL-----GTSS-----APPPKKS 253

  Fly   385 ELASSGNGQRHSSVGNTSL-TYSTCGGLSSGG-------------GALAGH----GSGGGVSGST 431
            .....|:|.......|.:: |..|.|.:..|.             |....|    ...|..|.:.
  Rat   254 LNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAP 318

  Fly   432 GLLGSPHHK----KLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPF--ETMHVPASLSS 490
            ..|...:.:    |.:..||:|:|...||||||..|.:|||||||:||:.||  .:.|:||.|.:
  Rat   319 ACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGA 383

  Fly   491 LFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRC 526
            :..||||:||||||:|||..|:||:..|::|:  :|
  Rat   384 IINWLGYSNSLLNPVIYAYFNKDFQNAFKKII--KC 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_001263131.1	7tm_4	173..>342	CDD:304433	84/174 (48%)
5-HT7	NP_001263131.1	7tm_1	179..507	CDD:278431	149/358 (42%)
Htr1a	NP_036717.1	7tm_4	48..>169	CDD:304433	60/120 (50%)
		7tm_1	53..400	CDD:278431	149/358 (42%)
		Agonist binding. /evidence=ECO:0000250	112..121		4/8 (50%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250	133..135		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	235..261		11/35 (31%)
		Agonist binding. /evidence=ECO:0000250	358..362		3/3 (100%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250	396..400		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BCYC
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002041
OrthoInspector	1	1.000	-	-		otm44443
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810