Protein Alignment 5-HT7 and Drd2

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_036679.1
• Gene: Drd2 / 24318
• RGDID: 2520
• Length: 444
• Species: Rattus norvegicus
• Alignment Length: 421
• Identity: 143/421 - (33%)
• Similarity: 216/421 - (51%)
• Gaps: 74/421 - (17%)

  Fly   164 FVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKW 228
            :.:::|.::|...|.||||||:||...:.|:...|||:||||::||.||.||||..:..||:.:|
  Rat    36 YYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEW 100

  Fly   229 NFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVK-RTPRRMMLCVGIVWLAAAC 292
            .|..:.|||:|:.||:.||||||||||||:|||.|:..|:.|..: .:.||:.:.:.|||:.:..
  Rat   101 KFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFT 165

  Fly   293 ISLPPLLILGNEHEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEEK 357
            ||.|.|..|.|..::|     |.:. |.|:.:|:::.|||:|..|.|.||.:|:     |||.::
  Rat   166 ISCPLLFGLNNTDQNE-----CIIA-NPAFVVYSSIVSFYVPFIVTLLVYIKIY-----IVLRKR 219

  Fly   358 RAQTHLQQA----------------------------LNGTGS--------PSAPQAPPLGHTEL 386
            |.:.:.:::                            :...||        .:|.:|..|....|
  Rat   220 RKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEML 284

  Fly   387 ASSGNGQ--RHSSV----GNTSLTYSTCGGLSSGGGALAGHGSGGGV-----------------S 428
            :|:...:  |:|.:    ...:|...:..||.|...:.|.....|..                 :
  Rat   285 SSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPN 349

  Fly   429 GSTGL-LGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPFETMHVPASLSSLF 492
            |.|.. |.:...:||..|  |||||:..|.|::..|.:|||||||..::......::|..|.|.|
  Rat   350 GKTRTSLKTMSRRKLSQQ--KEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAF 412

  Fly   493 LWLGYANSLLNPIIYATLNRDFRKPFQEILY 523
            .||||.||.:|||||.|.|.:|||.|.:||:
  Rat   413 TWLGYVNSAVNPIIYTTFNIEFRKAFMKILH 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	140/414 (34%)
		TM helix 1	164..190	CDD:320452	11/25 (44%)
		TM helix 2	197..223	CDD:320452	15/25 (60%)
		TM helix 3	235..265	CDD:320452	22/29 (76%)
		TM helix 4	277..299	CDD:320452	8/21 (38%)
		TM helix 5	319..348	CDD:320452	12/28 (43%)
		TM helix 6	447..477	CDD:320452	15/29 (52%)
		TM helix 7	486..511	CDD:320452	15/24 (63%)
Drd2	NP_036679.1	7tmA_D2_dopamine_R	35..438	CDD:320435	140/414 (34%)
		TM helix 1	36..62	CDD:320435	11/25 (44%)
		TM helix 2	69..92	CDD:320435	15/22 (68%)
		TM helix 3	107..137	CDD:320435	22/29 (76%)
		TM helix 4	152..170	CDD:320435	5/17 (29%)
		TM helix 5	186..211	CDD:320435	11/24 (46%)
		Interaction with PPP1R9B. /evidence=ECO:0000269|PubMed:10391935	211..374		31/169 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..329		9/46 (20%)
		TM helix 6	367..397	CDD:320435	16/31 (52%)
		TM helix 7	406..431	CDD:320435	15/24 (63%)