Protein Alignment 5-HT7 and Adra2b

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_612514.2
• Gene: Adra2b / 24174
• RGDID: 2057
• Length: 453
• Species: Rattus norvegicus
• Alignment Length: 435
• Identity: 142/435 - (32%)
• Similarity: 205/435 - (47%)
• Gaps: 87/435 - (20%)

  Fly   165 VSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWN 229
            ::..:..:||.|:.||.||.:||...|.||.|.|..|||||.:|:.||.|::|.:|..|:|..|.
  Rat    20 IASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWY 84

  Fly   230 FGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACIS 294
            |....|:::::.|||.||:||::|||||:|||.|:::.|||..||||||:...:..|||.||.||
  Rat    85 FWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVIS 149

  Fly   295 LPPLLILGNEHEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVL----- 354
            ||||:..|::..:..|.|.|.:.|...|.:.:::|||:.|..:|:.||.:|:..|:|...
  Rat   150 LPPLIYKGDQRPEPRGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGA 214

  Fly   355 -------EEKRAQ----------------THLQQALNGTGSPSAPQAPPLGHT------------ 384
                   |.|:.|                :.|.......|.|..|:....|.|
  Rat   215 KRGSGEGESKKPQPVAGGVPTSAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPT 279

  Fly   385 --ELASSGNGQRHSSVGNT---------------------SLTYSTCGG-----------LSSGG 415
              .|..||.||:..:.|.|                     :...|.|..           .:..|
  Rat   280 WSALPRSGQGQKKGTSGATAEEGDEEDEEEVEECEPQTLPASPASVCNPPLQQPQTSRVLATLRG 344

  Fly   416 GALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFI---LALIR 477
            ..|.|...|         :.|....:.|.||::||:.:..|.:::..|.|||.|||.   |..|.
  Rat   345 QVLLGKNVG---------VASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAIC 400

  Fly   478 PFETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEIL 522
            | :...||..|...|.|:||.||.|||:||...|:|||:.|:.||
  Rat   401 P-QHCKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRIL 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	139/429 (32%)
		TM helix 1	164..190	CDD:320452	9/24 (38%)
		TM helix 2	197..223	CDD:320452	12/25 (48%)
		TM helix 3	235..265	CDD:320452	17/29 (59%)
		TM helix 4	277..299	CDD:320452	12/21 (57%)
		TM helix 5	319..348	CDD:320452	9/28 (32%)
		TM helix 6	447..477	CDD:320452	11/32 (34%)
		TM helix 7	486..511	CDD:320452	12/24 (50%)
Adra2b	NP_612514.2	7tmA_alpha2B_AR	12..440	CDD:320444	139/429 (32%)
		TM helix 1	19..45	CDD:320444	9/24 (38%)
		TM helix 2	52..78	CDD:320444	12/25 (48%)
		TM helix 3	90..120	CDD:320444	17/29 (59%)
		TM helix 4	132..155	CDD:320444	13/22 (59%)
		TM helix 5	174..203	CDD:320444	9/28 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	213..331		18/117 (15%)
		TM helix 6	367..397	CDD:320444	10/29 (34%)
		TM helix 7	408..433	CDD:320444	12/24 (50%)