Protein Alignment 5-HT7 and ser-5

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_492273.2
• Gene: ser-5 / 184572
• WormBaseID: WBGene00008890
• Length: 454
• Species: Caenorhabditis elegans
• Alignment Length: 398
• Identity: 119/398 - (29%)
• Similarity: 191/398 - (47%)
• Gaps: 53/398 - (13%)

  Fly   119 IVSYQGITSSNLGDSNTTLVPLSDTPLLLEEFAAGEFVLPPLTSIFVSIVLLIVILGTVVGNVLV 183
            |....||::.|..|..:.:.......:|.|:...|| .|||...:.:.|..:|:||.|:.||:||
 Worm    20 IAKLAGISTGNESDVVSEMCKEQLRIILREKLRTGE-QLPPAVLVLLCIPAVIIILLTIFGNLLV 83

  Fly   184 CIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTA 248
            ......|.  |.....|:.:|.|:|..|.::|:||..:|.:..||.||..||.:||:.||..||.
 Worm    84 LFFKARVG--RTNTTLLVWNLGLTDFLVGVIVLPMGAVYLIYRKWIFGRFLCRLWVAADVTFCTC 146

  Fly   249 SILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLILGNEHEDEEGQPI 313
            |::.:|.||||||||:|:||.|....|..:::..:.|:|:.::.|.|..:.....|..|:.   :
 Worm   147 SVVTICVISVDRYLAVTRPLRYKSIVTKTKVISVMTIIWIFSSSILLTTVRWEQPECYDDS---L 208

  Fly   314 CTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEEKRAQTHLQQALNGTGSPSAPQA 378
            |.|.....:..::.:.:|::|.||.|.:|::|::.||           :.|:||:
 Worm   209 CFVGNEIRHLAHSVVFAFFLPASVTLTLYWRIYKLAR-----------NRQKALD---------- 252

  Fly   379 PPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLR 443
              .|...:.    |...:.:.||....:|          |..|      .|.|.  |...|:  |
 Worm   253 --RGFLMIL----GSNMNFLTNTLSQQTT----------LRVH------FGKTN--GMVEHQ--R 291

  Fly   444 FQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPFETMHVPASLSSLFLWLGYANSLLNPIIYA 508
            ..|...::.:.|||::..:|..||||||.|.|.....:..||.....:..||||.||:||||||:
 Worm   292 RVLRTHERIAKTLGVVSCSFLFCWLPFFGLYLTNYKCSGCVPPIAIDVASWLGYCNSMLNPIIYS 356

  Fly   509 TLNRDFRK 516
            ...::|::
 Worm   357 FTVKEFKR 364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	107/354 (30%)
		TM helix 1	164..190	CDD:320452	9/25 (36%)
		TM helix 2	197..223	CDD:320452	8/25 (32%)
		TM helix 3	235..265	CDD:320452	17/29 (59%)
		TM helix 4	277..299	CDD:320452	4/21 (19%)
		TM helix 5	319..348	CDD:320452	7/28 (25%)
		TM helix 6	447..477	CDD:320452	12/29 (41%)
		TM helix 7	486..511	CDD:320452	12/24 (50%)
ser-5	NP_492273.2	7tmA_amine_R-like	64..365	CDD:320098	107/353 (30%)
		TM helix 1	64..88	CDD:320098	9/23 (39%)
		TM helix 2	95..122	CDD:320098	9/26 (35%)
		TM helix 3	133..163	CDD:320098	17/29 (59%)
		TM helix 4	175..195	CDD:320098	4/19 (21%)
		TM helix 5	214..294	CDD:320098	24/126 (19%)
		TM helix 6	295..325	CDD:320098	12/29 (41%)
		TM helix 7	334..359	CDD:320098	12/24 (50%)