DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 5-HT7 and octr-1

DIOPT Version :9

Sequence 1:	NP_001263131.1	Gene:	5-HT7 / 43669	FlyBaseID:	FBgn0004573	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001024569.1	Gene:	octr-1 / 184469	WormBaseID:	WBGene00006411	Length:	408	Species:	Caenorhabditis elegans

Alignment Length:	424	Identity:	146/424 - (34%)
Similarity:	221/424 - (52%)	Gaps:	48/424 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 NLGDSNTTLVPLSDTPLLLEEFAAGEFVLPPLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKL 193
            |..:|:|.:..|:          .||.||  ..|..::::|||:.     ||:||.:.|...|||
Worm     5 NCSESDTKVACLN----------LGEAVL--TISSMLTVMLLIIF-----GNLLVVVTVYRDRKL 52

  Fly   194 R-RPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAIS 257
            | :..|:|:||||::|:.|.|||||:.|.||::.:|..|.:||:||::.|||..|||||::||||
Worm    53 RMQRQNWLIVSLAVADMLVGLLVMPLTLTYEIVGEWTMGNILCEIWLALDVLFVTASILHICAIS 117

  Fly   258 VDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLILGNEHEDEEGQPICTVCQNFAY 322
            :|||.::|.||.|...|||.||.:.:|:.|:.:..|.|||  |.|...|..||:  |:|..:..|
Worm   118 LDRYFSVTSPLTYPATRTPLRMFIYIGVSWIVSLLICLPP--IFGWRPERAEGE--CSVSTDLGY 178

  Fly   323 QIYATLGSFYIPLSVMLFVYYQIF----RAARRIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGH 383
            .:|::|||||||:.:::.||.:|:    |.:|:.:.|.:| :.|....|....|.:.........
Worm   179 VLYSSLGSFYIPVVILIIVYAKIYSITIRHSRQRLKETER-RDHTLNMLTIRSSTNERYNMEYEL 242

  Fly   384 TELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPH---------- 438
            .|.:.....::...|.|..:....|..|......|...|....::..|.....|.
Worm   243 EENSDPIEDEKEKVVTNRDMINKVCWQLRKISEELPRQGVKVSIALDTNHNSPPASDLTRKLEEK 307

  Fly   439 ---HKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPFETMHVPASLSSLFLWLGYANS 500
               .|:.|...|||::|:..||||:|||.:.|||||::.:|..| ....|..:...|.||||.||
Worm   308 KFCEKRKRKLKAKERQATLLLGIILSAFILSWLPFFLIYVIGAF-GHEAPPLVFKFFFWLGYCNS 371

  Fly   501 LLNPIIYATLNRDFRKPFQEILYFRCSSLNTMMR 534
            .:||:||...||:|::..       |..|:...|
Worm   372 GINPVIYTVFNREFKRGL-------CKQLHKFER 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_001263131.1	7tm_4	173..>342	CDD:304433	77/169 (46%)
5-HT7	NP_001263131.1	7tm_1	179..507	CDD:278431	126/345 (37%)
octr-1	NP_001024569.1	7tmA_alpha2_AR	22..389	CDD:320187	137/379 (36%)
		TM helix 1	24..48	CDD:320187	9/28 (32%)
		TM helix 2	58..80	CDD:320187	13/21 (62%)
		TM helix 3	96..118	CDD:320187	13/21 (62%)
		TM helix 4	141..157	CDD:320187	4/15 (27%)
		TM helix 5	176..199	CDD:320187	10/22 (45%)
		TM helix 6	322..347	CDD:320187	13/24 (54%)
		TM helix 7	357..382	CDD:320187	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3253
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940