Protein Alignment 5-HT7 and DRD3

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_000787.2
• Gene: DRD3 / 1814
• HGNCID: 3024
• Length: 400
• Species: Homo sapiens
• Alignment Length: 393
• Identity: 148/393 - (37%)
• Similarity: 202/393 - (51%)
• Gaps: 75/393 - (19%)

  Fly   172 VILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVL-EKWNFGPLLC 235
            :||..|.||.|||:||...|.|:...|||:||||::||.||.||||..:..||. ..|||..:.|
Human    39 LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICC 103

  Fly   236 DIWVSFDVLCCTASILNLCAISVDRYLAITKPLEY--GVKRTP-RRMMLCVGIVWLAAACISLPP 297
            |::|:.||:.||||||||||||:|||.|:..|:.|  |..::. ||:.|.:..||:.|..:|.|
Human   104 DVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCP- 167

  Fly   298 LLILGNEHEDEEGQPICTVC--QNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEEKRAQ 360
             |:.|   .:..|.|  |||  .|..:.||:::.|||:|..|.:.||.:|:     :||:::|.:
Human   168 -LLFG---FNTTGDP--TVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIY-----VVLKQRRRK 221

  Fly   361 THL--QQALNGTGSPSAPQ---APPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAG 420
            ..|  |.:...:..|..||   :|...|.||      :|:         ||.|...:.||.....
Human   222 RILTRQNSQCNSVRPGFPQQTLSPDPAHLEL------KRY---------YSICQDTALGGPGFQE 271

  Fly   421 HG----------------------------SGGGVSGSTGLLG--SPHHKKLRFQLAKEKKASTT 455
            .|                            |.|.:|.|. .||  .|....||     ||||:..
Human   272 RGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSL-KLGPLQPRGVPLR-----EKKATQM 330

  Fly   456 LGIIMSAFTVCWLPFFILALIRPF-ETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQ 519
            :.|::.||.|||||||:..::... :|.||...|.|...||||.||.|||:||.|.|.:|||.|.
Human   331 VAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFL 395

  Fly   520 EIL 522
            :||
Human   396 KIL 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	145/387 (37%)
		TM helix 1	164..190	CDD:320452	10/17 (59%)
		TM helix 2	197..223	CDD:320452	15/25 (60%)
		TM helix 3	235..265	CDD:320452	21/29 (72%)
		TM helix 4	277..299	CDD:320452	8/21 (38%)
		TM helix 5	319..348	CDD:320452	11/28 (39%)
		TM helix 6	447..477	CDD:320452	14/29 (48%)
		TM helix 7	486..511	CDD:320452	14/24 (58%)
DRD3	NP_000787.2	7tmA_D3_dopamine_R	30..394	CDD:320436	145/387 (37%)
		TM helix 1	31..57	CDD:320436	10/17 (59%)
		TM helix 2	64..87	CDD:320436	15/22 (68%)
		TM helix 3	103..133	CDD:320436	21/29 (72%)
		TM helix 4	150..168	CDD:320436	6/19 (32%)
		TM helix 5	185..210	CDD:320436	10/24 (42%)
		TM helix 6	322..352	CDD:320436	16/34 (47%)
		TM helix 7	362..387	CDD:320436	14/24 (58%)