Protein Alignment 5-HT7 and DRD2

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_000786.1
• Gene: DRD2 / 1813
• HGNCID: 3023
• Length: 443
• Species: Homo sapiens
• Alignment Length: 415
• Identity: 149/415 - (35%)
• Similarity: 212/415 - (51%)
• Gaps: 71/415 - (17%)

  Fly   167 IVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFG 231
            :.|||.::  |.||||||:||...:.|:...|||:||||::||.||.||||..:..||:.:|.|.
Human    41 LTLLIAVI--VFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFS 103

  Fly   232 PLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVK-RTPRRMMLCVGIVWLAAACISL 295
            .:.|||:|:.||:.||||||||||||:|||.|:..|:.|..: .:.||:.:.:.|||:.:..||.
Human   104 RIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISC 168

  Fly   296 PPLLILGNEHEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEEKRAQ 360
            |.|..|.|..::|     |.:. |.|:.:|:::.|||:|..|.|.||.:|:...||   ..||..
Human   169 PLLFGLNNADQNE-----CIIA-NPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRR---RRKRVN 224

  Fly   361 T---------HLQQALNG-----------------TGS--------PSAPQAPPLGHTELASSGN 391
            |         ||:..|.|                 .||        .:|.:|..|....|:|:..
Human   225 TKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSP 289

  Fly   392 GQ--RHSSV----GNTSLTYSTCGGLSSGGGALAGHGSGGGV----------------SGSTGL- 433
            .:  |:|.:    ...:|...:..||.|...:.|.....|..                :|.|..
Human   290 PERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTS 354

  Fly   434 LGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPFETMHVPASLSSLFLWLGYA 498
            |.:...:||..|  |||||:..|.|::..|.:|||||||..::......::|..|.|.|.||||.
Human   355 LKTMSRRKLSQQ--KEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYV 417

  Fly   499 NSLLNPIIYATLNRDFRKPFQEILY 523
            ||.:|||||.|.|.:|||.|.:||:
Human   418 NSAVNPIIYTTFNIEFRKAFLKILH 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	146/408 (36%)
		TM helix 1	164..190	CDD:320452	12/22 (55%)
		TM helix 2	197..223	CDD:320452	15/25 (60%)
		TM helix 3	235..265	CDD:320452	22/29 (76%)
		TM helix 4	277..299	CDD:320452	8/21 (38%)
		TM helix 5	319..348	CDD:320452	12/28 (43%)
		TM helix 6	447..477	CDD:320452	15/29 (52%)
		TM helix 7	486..511	CDD:320452	15/24 (63%)
DRD2	NP_000786.1	7tmA_D2_dopamine_R	35..437	CDD:320435	146/408 (36%)
		TM helix 1	36..62	CDD:320435	12/22 (55%)
		TM helix 2	69..92	CDD:320435	15/22 (68%)
		TM helix 3	107..137	CDD:320435	22/29 (76%)
		TM helix 4	152..170	CDD:320435	5/17 (29%)
		TM helix 5	186..211	CDD:320435	11/24 (46%)
		Interaction with PPP1R9B. /evidence=ECO:0000250	211..373		36/166 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..332		10/50 (20%)
		TM helix 6	366..396	CDD:320435	16/31 (52%)
		TM helix 7	405..430	CDD:320435	15/24 (63%)