Protein Alignment 5-HT7 and tyra-2

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001033537.1
• Gene: tyra-2 / 180970
• WormBaseID: WBGene00017157
• Length: 468
• Species: Caenorhabditis elegans
• Alignment Length: 460
• Identity: 129/460 - (28%)
• Similarity: 206/460 - (44%)
• Gaps: 114/460 - (24%)

  Fly   155 FVLPP------LTSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVAL 213
            :|:.|      |..|.....|.:::|.|:..|.||.|.:....:|:...|.|:.:||.|||.:.|
 Worm     5 YVMSPVDETYTLFQILKGSALFLLVLWTIFANSLVFIVLYKNPRLQTVPNLLVGNLAFSDLALGL 69

  Fly   214 LVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRR 278
            :|:|::.:|.:..:|.|...||:::||.|:||.||||.||..:.:|||.|||.|:.|..||..|.
 Worm    70 IVLPLSSVYAIAGEWVFPDALCEVFVSADILCSTASIWNLSIVGLDRYWAITSPVAYMSKRNKRT 134

  Fly   279 MMLCVGIVWLAAACISLPPLLILGNE---------HEDEEGQPICTVCQNFAYQIYATLGSFYIP 334
            ..:.:..||:::|.|||.||  ||.:         :|.......||.....:|.:|:..|||:||
 Worm   135 AGIMILSVWISSALISLAPL--LGWKQTAQTPNLIYEKNNTVRQCTFLDLPSYTVYSATGSFFIP 197

  Fly   335 LSVMLFVYYQIFRA-----ARRIVLEEKRAQTH-LQQALNGT-------GSPSAPQAPPLGHTEL 386
            ..:|.|||::|::|     ||:|..::....:| :::.:..|       ..|::.:.......|.
 Worm   198 TLLMFFVYFKIYQAFAKHRARQIYRQKLAVSSHVIRKHIESTILHEISHVLPTSDEFAKEEEEEE 262

  Fly   387 ASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALA---------------GHGSGGGVSGS-TGLLG 435
            .|..:||..:.:||             |..|:.               .|.|...|:.: ||...
 Worm   263 DSESSGQVENGLGN-------------GNDAIIEEDECEDEDSDEKRDDHTSMTTVTATVTGPTE 314

  Fly   436 SPH----------------------------------------HKKLRFQL-------------- 446
            :|:                                        ||..:.::
 Worm   315 APYMKREAKISKSVPIEKESAIQKREAKPMRSVMAISYEKVKRHKNRKERIYRKSLQRKPKAISA 379

  Fly   447 AKEKKASTTLGIIMSAFTVCWLPFFILALIRPFETMHVPASLSSLFL-WLGYANSLLNPIIYATL 510
            |||::....||||:..|||||.|||.:.::..|.....|.:...:|: ||||:||.:|||||...
 Worm   380 AKERRGVKVLGIILGCFTVCWAPFFTMYVLVQFCKDCSPNAHIEMFITWLGYSNSAMNPIIYTVF 444

  Fly   511 NRDFR 515
            |||::
 Worm   445 NRDYQ 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	126/446 (28%)
		TM helix 1	164..190	CDD:320452	7/25 (28%)
		TM helix 2	197..223	CDD:320452	10/25 (40%)
		TM helix 3	235..265	CDD:320452	16/29 (55%)
		TM helix 4	277..299	CDD:320452	8/21 (38%)
		TM helix 5	319..348	CDD:320452	12/28 (43%)
		TM helix 6	447..477	CDD:320452	15/29 (52%)
		TM helix 7	486..511	CDD:320452	12/25 (48%)
tyra-2	NP_001033537.1	7tmA_amine_R-like	20..452	CDD:320098	125/445 (28%)
		TM helix 1	20..46	CDD:320098	7/25 (28%)
		TM helix 2	53..80	CDD:320098	11/26 (42%)
		TM helix 3	91..121	CDD:320098	16/29 (55%)
		TM helix 4	133..153	CDD:320098	7/19 (37%)
		TM helix 5	182..379	CDD:320098	35/209 (17%)
		TM helix 6	380..410	CDD:320098	15/29 (52%)
		TM helix 7	420..445	CDD:320098	12/24 (50%)