DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 5-HT7 and ser-4

DIOPT Version :9

Sequence 1:	NP_001263131.1	Gene:	5-HT7 / 43669	FlyBaseID:	FBgn0004573	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_497452.1	Gene:	ser-4 / 175322	WormBaseID:	WBGene00004779	Length:	445	Species:	Caenorhabditis elegans

Alignment Length:	434	Identity:	139/434 - (32%)
Similarity:	221/434 - (50%)	Gaps:	42/434 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 NTTLVPLSDTPLLLEEFAAGEFVL---------------PPLTSIFVSIVLLIVILGTVVGNVLV 183
            |.|..|.|....||...|.|..::               |.:.::.::.|||::||...:||:.|
Worm     8 NLTASPSSQPATLLSAVARGTHLVDQFPAHAEIFSDIERPLVQTVILASVLLVLILSCFIGNLFV 72

  Fly   184 CIAVCMVRKLR-RPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCT 247
            .:|:.|.|.|| ||..||:.|||::||.|.::|.|:...:.|...||.|.::||.|:|.|||.||
Worm    73 ILAIIMERDLRGRPQYYLIFSLAVADLLVGMIVTPLGAWFTVTGTWNLGVVVCDFWISVDVLVCT 137

  Fly   248 ASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLILGNEHEDEE--G 310
            ||||:|.||::|||.:|| .:.|...|||:|:.|.:.::|..:..|||.|.....:|...:.  .
Worm   138 ASILHLVAIALDRYWSIT-DICYVQNRTPKRITLMLAVIWFTSLLISLAPFAGWKDEGFSDRVLK 201

  Fly   311 QPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEEKRAQTHL---------QQA 366
            ..:|.:.|..:||:::|..:|||||..::.||::|.|||::....|:..:|.:         ::|
Worm   202 SHVCLISQQISYQVFSTATAFYIPLIAIICVYWKIMRAAKKRFKRERDRRTVIRPPPDAIDEKKA 266

  Fly   367 LNGTGSPSAPQAPPLGHTEL-ASSGNGQRHSSVGNTSLTYSTCGGLSSGGGAL--AGHGSGGGVS 428
            :....|...|..|.:..::: |:.|.|.:.:|:.|......:....|.....:  ..|..|...:
Worm   267 MMPKKSKKCPLPPAVVISDIQANGGTGGKTNSIKNPPRHNESSSSASEEERTMTQTNHAPGDVTT 331

  Fly   429 GST-----------GLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPFETM 482
            ..|           |::......|...::.:|:||..||.||...|..||.|||::::.||....
Worm   332 QETKIDEENGRSKPGIVKRRRRTKESNEMKRERKAWRTLAIITGTFVACWTPFFLVSIYRPICGC 396

  Fly   483 HVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRC 526
            .:...|..:.|||||.||.||||||...::|||..|:.|:...|
Worm   397 QISPVLEQVTLWLGYLNSALNPIIYTVFSQDFRAAFKRIIKRMC 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_001263131.1	7tm_4	173..>342	CDD:304433	69/171 (40%)
5-HT7	NP_001263131.1	7tm_1	179..507	CDD:278431	117/353 (33%)
ser-4	NP_497452.1	7tmA_5-HT1A_invertebrates	52..432	CDD:320454	127/380 (33%)
		TM helix 1	53..79	CDD:320454	9/25 (36%)
		TM helix 2	87..113	CDD:320454	10/25 (40%)
		TM helix 3	125..155	CDD:320454	19/29 (66%)
		TM helix 4	166..188	CDD:320454	7/21 (33%)
		TM helix 5	210..239	CDD:320454	11/28 (39%)
		TM helix 6	361..391	CDD:320454	13/29 (45%)
		TM helix 7	400..425	CDD:320454	14/24 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BCYC
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3253
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840