Protein Alignment 5-HT7 and ser-4

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_497452.1
• Gene: ser-4 / 175322
• WormBaseID: WBGene00004779
• Length: 445
• Species: Caenorhabditis elegans
• Alignment Length: 434
• Identity: 139/434 - (32%)
• Similarity: 221/434 - (50%)
• Gaps: 42/434 - (9%)

  Fly   134 NTTLVPLSDTPLLLEEFAAGEFVL---------------PPLTSIFVSIVLLIVILGTVVGNVLV 183
            |.|..|.|....||...|.|..::               |.:.::.::.|||::||...:||:.|
 Worm     8 NLTASPSSQPATLLSAVARGTHLVDQFPAHAEIFSDIERPLVQTVILASVLLVLILSCFIGNLFV 72

  Fly   184 CIAVCMVRKLR-RPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCT 247
            .:|:.|.|.|| ||..||:.|||::||.|.::|.|:...:.|...||.|.::||.|:|.|||.||
 Worm    73 ILAIIMERDLRGRPQYYLIFSLAVADLLVGMIVTPLGAWFTVTGTWNLGVVVCDFWISVDVLVCT 137

  Fly   248 ASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLILGNEHEDEE--G 310
            ||||:|.||::|||.:|| .:.|...|||:|:.|.:.::|..:..|||.|.....:|...:.  .
 Worm   138 ASILHLVAIALDRYWSIT-DICYVQNRTPKRITLMLAVIWFTSLLISLAPFAGWKDEGFSDRVLK 201

  Fly   311 QPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEEKRAQTHL---------QQA 366
            ..:|.:.|..:||:::|..:|||||..::.||::|.|||::....|:..:|.:         ::|
 Worm   202 SHVCLISQQISYQVFSTATAFYIPLIAIICVYWKIMRAAKKRFKRERDRRTVIRPPPDAIDEKKA 266

  Fly   367 LNGTGSPSAPQAPPLGHTEL-ASSGNGQRHSSVGNTSLTYSTCGGLSSGGGAL--AGHGSGGGVS 428
            :....|...|..|.:..::: |:.|.|.:.:|:.|......:....|.....:  ..|..|...:
 Worm   267 MMPKKSKKCPLPPAVVISDIQANGGTGGKTNSIKNPPRHNESSSSASEEERTMTQTNHAPGDVTT 331

  Fly   429 GST-----------GLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPFETM 482
            ..|           |::......|...::.:|:||..||.||...|..||.|||::::.||....
 Worm   332 QETKIDEENGRSKPGIVKRRRRTKESNEMKRERKAWRTLAIITGTFVACWTPFFLVSIYRPICGC 396

  Fly   483 HVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRC 526
            .:...|..:.|||||.||.||||||...::|||..|:.|:...|
 Worm   397 QISPVLEQVTLWLGYLNSALNPIIYTVFSQDFRAAFKRIIKRMC 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	127/380 (33%)
		TM helix 1	164..190	CDD:320452	9/25 (36%)
		TM helix 2	197..223	CDD:320452	10/25 (40%)
		TM helix 3	235..265	CDD:320452	19/29 (66%)
		TM helix 4	277..299	CDD:320452	7/21 (33%)
		TM helix 5	319..348	CDD:320452	11/28 (39%)
		TM helix 6	447..477	CDD:320452	13/29 (45%)
		TM helix 7	486..511	CDD:320452	14/24 (58%)
ser-4	NP_497452.1	7tmA_5-HT1A_invertebrates	52..432	CDD:320454	127/380 (33%)
		TM helix 1	53..79	CDD:320454	9/25 (36%)
		TM helix 2	87..113	CDD:320454	10/25 (40%)
		TM helix 3	125..155	CDD:320454	19/29 (66%)
		TM helix 4	166..188	CDD:320454	7/21 (33%)
		TM helix 5	210..239	CDD:320454	11/28 (39%)
		TM helix 6	361..391	CDD:320454	13/29 (45%)
		TM helix 7	400..425	CDD:320454	14/24 (58%)