DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 5-HT7 and Htr6

DIOPT Version :9

Sequence 1:	NP_001263131.1	Gene:	5-HT7 / 43669	FlyBaseID:	FBgn0004573	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001364025.1	Gene:	Htr6 / 15565	MGIID:	1196627	Length:	440	Species:	Mus musculus

Alignment Length:	366	Identity:	121/366 - (33%)
Similarity:	167/366 - (45%)	Gaps:	61/366 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 PPLT--SIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMAL 220
            ||..  |.:|:..|.:||:.|...|.|:...:|....||...|:.||||..|||.|.|:|||.|:
Mouse    20 PPAPGGSGWVAAALCVVIVLTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAM 84

  Fly   221 LYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRT-PRRMMLCVG 284
            |..:..:|.....||.:|.:|||:||:|||||||.||:||||.|..||.|.::.| ||.:.|.:|
Mouse    85 LNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILG 149

  Fly   285 IVWLAAACISLPPLLI----LGNEHEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQI 345
             .|..||..|..|||:    ||.......||  |.:..:..|.:.|:..:|::|...:.|.|.:|
Mouse   150 -AWSLAALASFLPLLLGWHELGKARTSAPGQ--CRLLASLPYVLVASGVTFFLPSGAICFTYCRI 211

  Fly   346 FRAARRIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGG 410
            ..|||:..::.....|....|.....:...|:.|..|.....|.....:||
Mouse   212 LLAARKQAVQVASLTTGTATAGQALETLQVPRTPRPGMESADSRRLTTKHS-------------- 262

  Fly   411 LSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILAL 475
                                                .|..|||.||||::|.|.|.|||||:.::
Mouse   263 ------------------------------------RKALKASLTLGILLSMFFVTWLPFFVASI 291

  Fly   476 IRPFETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRK 516
            .:.......| .|..:..||||.||.:|||||....|||::
Mouse   292 AQAVCDCISP-GLFDVLTWLGYCNSTMNPIIYPLFMRDFKR 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_001263131.1	7tm_4	173..>342	CDD:304433	70/173 (40%)
5-HT7	NP_001263131.1	7tm_1	179..507	CDD:278431	108/332 (33%)
Htr6	NP_001364025.1	7tmA_5-HT6	29..333	CDD:320182	118/357 (33%)
		TM helix 1	29..53	CDD:320182	7/23 (30%)
		TM helix 2	62..84	CDD:320182	13/21 (62%)
		TM helix 3	100..122	CDD:320182	14/21 (67%)
		TM helix 4	145..161	CDD:320182	6/16 (38%)
		TM helix 5	186..209	CDD:320182	5/22 (23%)
		TM helix 6	269..291	CDD:320182	13/21 (62%)
		TM helix 7	301..326	CDD:320182	13/25 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910