Protein Alignment 5-HT7 and Htr6

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_067333.1
• Gene: Htr6 / 15565
• MGIID: 1196627
• Length: 440
• Species: Mus musculus
• Alignment Length: 366
• Identity: 121/366 - (33%)
• Similarity: 167/366 - (45%)
• Gaps: 61/366 - (16%)

  Fly   158 PPLT--SIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMAL 220
            ||..  |.:|:..|.:||:.|...|.|:...:|....||...|:.||||..|||.|.|:|||.|:
Mouse    20 PPAPGGSGWVAAALCVVIVLTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAM 84

  Fly   221 LYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRT-PRRMMLCVG 284
            |..:..:|.....||.:|.:|||:||:|||||||.||:||||.|..||.|.::.| ||.:.|.:|
Mouse    85 LNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILG 149

  Fly   285 IVWLAAACISLPPLLI----LGNEHEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQI 345
             .|..||..|..|||:    ||.......||  |.:..:..|.:.|:..:|::|...:.|.|.:|
Mouse   150 -AWSLAALASFLPLLLGWHELGKARTSAPGQ--CRLLASLPYVLVASGVTFFLPSGAICFTYCRI 211

  Fly   346 FRAARRIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGG 410
            ..|||:..::.....|....|.....:...|:.|..|.....|.....:||
Mouse   212 LLAARKQAVQVASLTTGTATAGQALETLQVPRTPRPGMESADSRRLTTKHS-------------- 262

  Fly   411 LSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILAL 475
                                                .|..|||.||||::|.|.|.|||||:.::
Mouse   263 ------------------------------------RKALKASLTLGILLSMFFVTWLPFFVASI 291

  Fly   476 IRPFETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRK 516
            .:.......| .|..:..||||.||.:|||||....|||::
Mouse   292 AQAVCDCISP-GLFDVLTWLGYCNSTMNPIIYPLFMRDFKR 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	118/359 (33%)
		TM helix 1	164..190	CDD:320452	8/25 (32%)
		TM helix 2	197..223	CDD:320452	15/25 (60%)
		TM helix 3	235..265	CDD:320452	20/29 (69%)
		TM helix 4	277..299	CDD:320452	8/21 (38%)
		TM helix 5	319..348	CDD:320452	7/28 (25%)
		TM helix 6	447..477	CDD:320452	16/29 (55%)
		TM helix 7	486..511	CDD:320452	12/24 (50%)
Htr6	NP_067333.1	7tmA_5-HT6	29..333	CDD:320182	118/357 (33%)
		TM helix 1	29..54	CDD:320182	8/24 (33%)
		TM helix 2	61..87	CDD:320182	15/25 (60%)
		TM helix 3	99..129	CDD:320182	20/29 (69%)
		TM helix 4	141..164	CDD:320182	10/23 (43%)
		TM helix 5	185..214	CDD:320182	7/28 (25%)
		TM helix 6	263..293	CDD:320182	16/29 (55%)
		TM helix 7	301..326	CDD:320182	13/25 (52%)