Protein Alignment 5-HT7 and Htr5b

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_034613.2
• Gene: Htr5b / 15564
• MGIID: 96284
• Length: 370
• Species: Mus musculus
• Alignment Length: 448
• Identity: 143/448 - (31%)
• Similarity: 219/448 - (48%)
• Gaps: 93/448 - (20%)

  Fly    82 IASASSTGSGSGSGSGSGSGSGSGSYGLASMNSSPIAIVSYQGITSSNLGDSNTTLVPLSDTPLL 146
            :::.|....|.....|..|.|.|.|.| .||.|:|
Mouse     3 VSNLSGATPGLAFPPGPESCSDSPSSG-RSMGSTP------------------------------ 36

  Fly   147 LEEFAAGEFVL----PPLTSIFVSIVLLIVIL--GTVVGNVLVCIAVCMVRKLRRPCNYLLVSLA 205
                  |..:|    ||.::..|.:|.|:|:|  .|.:.|:||.:.:..||...|..:.|:.|.|
Mouse    37 ------GGLILPGREPPFSAFTVLVVTLLVLLIVATFLWNLLVLVTILRVRAFHRVPHNLVASTA 95

  Fly   206 LSDLCVALLVMPMALLYE--VLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPL 268
            :||:.||.||||::|:.|  |..:|..|..||.:|:|||||||||||.|:.||::|||..||:.|
Mouse    96 VSDVLVAALVMPLSLVSELSVGRRWQLGRSLCHVWISFDVLCCTASIWNVAAIALDRYWTITRHL 160

  Fly   269 EYGVKRTPRRMMLCVGIVWLAAACISLPPLLILGNEHEDEEGQPICTVCQNFAYQIYATLGSFYI 333
            :|.::...|...|.:.|.|..:|.|:|.|||....|..|...|. |.|.|..:|.:::|.|:||:
Mouse   161 QYTLRTRSRASALMIAITWALSALIALAPLLFGWGEAYDARLQR-CQVSQEPSYAVFSTCGAFYL 224

  Fly   334 PLSVMLFVYYQIFRAARRIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSV 398
            ||:|:||||::|::||:......:||...|      ..:..|.:|||  .:|:..:  .:|.::|
Mouse   225 PLAVVLFVYWKIYKAAKFRFGRRRRAVVPL------PATTQAKEAPP--ESEMVFT--ARRRATV 279

  Fly   399 GNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAF 463
                 |:.|.|.                                .::..|||:|:..:||::..|
Mouse   280 -----TFQTSGD--------------------------------SWREQKEKRAAMMVGILIGVF 307

  Fly   464 TVCWLPFFILALIRPFETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEI 521
            .:||:|||:..||.|.....:|....|:||||||:||..||:||...|:::...|:.:
Mouse   308 VLCWIPFFLTELISPLCACSLPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAFKSL 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	126/358 (35%)
		TM helix 1	164..190	CDD:320452	9/27 (33%)
		TM helix 2	197..223	CDD:320452	12/25 (48%)
		TM helix 3	235..265	CDD:320452	19/29 (66%)
		TM helix 4	277..299	CDD:320452	8/21 (38%)
		TM helix 5	319..348	CDD:320452	13/28 (46%)
		TM helix 6	447..477	CDD:320452	13/29 (45%)
		TM helix 7	486..511	CDD:320452	13/24 (54%)
Htr5b	NP_034613.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		11/33 (33%)
		7tm_GPCRs	65..362	CDD:475119	121/344 (35%)
		TM helix 2	88..110	CDD:410628	11/21 (52%)
		TM helix 3	128..150	CDD:410628	15/21 (71%)
		TM helix 4	173..189	CDD:410628	6/15 (40%)
		TM helix 5	211..234	CDD:410628	11/22 (50%)
		TM helix 6	297..319	CDD:410628	8/21 (38%)
		TM helix 7	330..355	CDD:410628	13/24 (54%)