Protein Alignment 5-HT7 and Htr5a

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_032340.2
• Gene: Htr5a / 15563
• MGIID: 96283
• Length: 357
• Species: Mus musculus
• Alignment Length: 411
• Identity: 136/411 - (33%)
• Similarity: 216/411 - (52%)
• Gaps: 71/411 - (17%)

  Fly   116 PIAIVSYQGITSSNLGDSNTTLVPLSDTPLLLEEFAAGEFVLPPLTSIFVSIVLLIVILG----- 175
            |:.:.|:...|.|:| :.|.:|    ||.:|...        .|..|.|  .||::.:||
Mouse     4 PVNLTSFSLSTPSSL-EPNRSL----DTEVLRPS--------RPFLSAF--RVLVLTLLGFLAAA 53

  Fly   176 TVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVL-EKWNFGPLLCDIWV 239
            |...|:||...:..||...|..:.|:.|:|:||:.||:||||::|::|:. .:|..|..||.:|:
Mouse    54 TFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWI 118

  Fly   240 SFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLILGNE 304
            :.|||||||||.|:.||::|||.:||:.|||.::...|...:.:.:.|..:..|||.|||....|
Mouse   119 ACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGE 183

  Fly   305 HEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAAR-RIVLEEKRAQTHLQQALN 368
            ...|..:. |.|.:..:|.:::|:|:||:||.|:||||::|:|||: |:...:..:.:.:.:|:.
Mouse   184 TYSEPSEE-CQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRMGSRKTNSVSPVPEAVE 247

  Fly   369 GTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGL 433
               ..:|.|.|.:..|        .||::|     |:.|                    .|.|
Mouse   248 ---VKNATQHPQMVFT--------VRHATV-----TFQT--------------------EGDT-- 274

  Fly   434 LGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPFETMHVPASLSSLFLWLGYA 498
                      ::..||::|:..:||::..|.:||.|||:..||.|..:..|||...|:||||||:
Mouse   275 ----------WREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYS 329

  Fly   499 NSLLNPIIYATLNRDFRKPFQ 519
            ||..||:||...||.:...|:
Mouse   330 NSFFNPLIYTAFNRSYSSAFK 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	123/361 (34%)
		TM helix 1	164..190	CDD:320452	9/30 (30%)
		TM helix 2	197..223	CDD:320452	12/25 (48%)
		TM helix 3	235..265	CDD:320452	17/29 (59%)
		TM helix 4	277..299	CDD:320452	6/21 (29%)
		TM helix 5	319..348	CDD:320452	13/28 (46%)
		TM helix 6	447..477	CDD:320452	12/29 (41%)
		TM helix 7	486..511	CDD:320452	14/24 (58%)
Htr5a	NP_032340.2	7tm_GPCRs	41..349	CDD:475119	122/356 (34%)
		TM helix 1	43..67	CDD:410628	6/23 (26%)
		TM helix 2	76..98	CDD:410628	11/21 (52%)
		TM helix 3	115..137	CDD:410628	13/21 (62%)
		TM helix 4	160..176	CDD:410628	4/15 (27%)
		TM helix 5	198..221	CDD:410628	11/22 (50%)
		TM helix 6	284..306	CDD:410628	8/21 (38%)
		TM helix 7	317..342	CDD:410628	14/24 (58%)