Protein Alignment 5-HT7 and Htr4

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_032339.2
• Gene: Htr4 / 15562
• MGIID: 109246
• Length: 388
• Species: Mus musculus
• Alignment Length: 397
• Identity: 130/397 - (32%)
• Similarity: 182/397 - (45%)
• Gaps: 95/397 - (23%)

  Fly   167 IVLL----IVILGTVVGNVLVCIAVCMVRKLRR-PCNYLLVSLALSDLCVALLVMPMALLYEVLE 226
            :|||    :|||..::||:||.:|||..|:||: ..||.:||||.:||.|::||||...:..|.:
Mouse    20 VVLLTFLAVVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQD 84

  Fly   227 KWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAI-TKPLEYGVKRTPRRMMLCVGIVWLAA 290
            .|.:|.:.|.:..|.|||..||||.:||.||:|||.|| .:||.|..|.||.|:.|.:|..|:..
Mouse    85 IWAYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVLP 149

  Fly   291 ACISLPPLL-----------ILGNEHEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQ 344
            ..||..|::           |...:.........|....|..|.|..::.:||||..:|:..||:
Mouse   150 MFISFLPIMQGWNNIGIVDVIEKRKFSHNSNSTWCVFMVNKPYAITCSVVAFYIPFLLMVLAYYR 214

  Fly   345 IFRAARRIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCG 409
            |:..|:    |..:....||:|  |..|.|.||.             ..:||:
Mouse   215 IYVTAK----EHAQQIQMLQRA--GATSESRPQP-------------ADQHST------------ 248

  Fly   410 GLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILA 474
                                         |:     :..|.||:.||.:||..|..||.|||:..
Mouse   249 -----------------------------HR-----MRTETKAAKTLCVIMGCFCFCWAPFFVTN 279

  Fly   475 LIRPFETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRCSSLNTMMRENYYQ 539
            ::.||....||..:.:.||||||.||.|||.:||.||:.||:.|..||   |..          .
Mouse   280 IVDPFIDYTVPEQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIIL---CCD----------D 331

  Fly   540 DQYGEPP 546
            ::|..||
Mouse   332 ERYKRPP 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	123/367 (34%)
		TM helix 1	164..190	CDD:320452	13/26 (50%)
		TM helix 2	197..223	CDD:320452	13/25 (52%)
		TM helix 3	235..265	CDD:320452	18/30 (60%)
		TM helix 4	277..299	CDD:320452	7/21 (33%)
		TM helix 5	319..348	CDD:320452	11/28 (39%)
		TM helix 6	447..477	CDD:320452	13/29 (45%)
		TM helix 7	486..511	CDD:320452	13/24 (54%)
Htr4	NP_032339.2	7tmA_5-HT4	20..323	CDD:320184	123/367 (34%)
		TM helix 1	21..47	CDD:320184	13/25 (52%)
		TM helix 2	55..81	CDD:320184	13/25 (52%)
		TM helix 3	93..123	CDD:320184	17/29 (59%)
		TM helix 4	136..159	CDD:320184	7/22 (32%)
		TM helix 5	189..218	CDD:320184	11/28 (39%)
		TM helix 6	252..282	CDD:320184	13/29 (45%)
		TM helix 7	291..316	CDD:320184	13/24 (54%)