Protein Alignment 5-HT7 and Htr2b

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_006529209.1
• Gene: Htr2b / 15559
• MGIID: 109323
• Length: 495
• Species: Mus musculus
• Alignment Length: 394
• Identity: 110/394 - (27%)
• Similarity: 188/394 - (47%)
• Gaps: 65/394 - (16%)

  Fly   164 FVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEK- 227
            :.::::|.||:.|:.||:||.:||.:.::|:...||.|:|||::||.|.|.|||:|||..:.|.
Mouse    55 WAALLILAVIIPTIGGNILVILAVALEKRLQYATNYFLMSLAIADLLVGLFVMPIALLTIMFEAI 119

  Fly   228 WNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAAC 292
            |.....||..|:..|||..||||::|||||:|||:||.||::.....:.....:.:.:|||.:..
Mouse   120 WPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRATAFIKITVVWLISIG 184

  Fly   293 ISLPPLLILGNEHEDEEGQPI----------------CTVCQN--FAYQIYATLGSFYIPLSVML 339
            :...||...|.........|:                |.:.::  .::.::.:|.:|:.||::|:
Mouse   185 MWGMPLFPYGQNASSGIAIPVPIKGIETDVINPHNVTCELTKDRFGSFMVFGSLAAFFAPLTIMV 249

  Fly   340 FVYY-QIFRAARRIVLEEKRAQTHLQQ------ALNGTGSPSAPQAPPLGHTELASSGNGQRHSS 397
            ..|: .|....::..|.:.:....|.:      .|....|.|:|:       ::|......|...
Mouse   250 VTYFLTIHTLQKKAYLVKNKPPQRLTRWTVPTVFLREDSSFSSPE-------KVAMLDGSHRDKI 307

  Fly   398 VGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSA 462
            :.|:| ..:....:||.|                        |:....::.|::||..||::...
Mouse   308 LPNSS-DETLMRRMSSVG------------------------KRSAQTISNEQRASKALGVVFFL 347

  Fly   463 FTVCWLPFFI----LALIRPFETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILY 523
            |.:.|.||||    |||........: .:|..:|:|:||.:|.:||:||...|:.||:.|..  |
Mouse   348 FLLMWCPFFITNLTLALCDSCNQTTL-KTLLEIFVWIGYVSSGVNPLIYTLFNKTFREAFGR--Y 409

  Fly   524 FRCS 527
            ..|:
Mouse   410 ITCN 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	107/383 (28%)
		TM helix 1	164..190	CDD:320452	10/25 (40%)
		TM helix 2	197..223	CDD:320452	16/25 (64%)
		TM helix 3	235..265	CDD:320452	18/29 (62%)
		TM helix 4	277..299	CDD:320452	4/21 (19%)
		TM helix 5	319..348	CDD:320452	7/31 (23%)
		TM helix 6	447..477	CDD:320452	14/33 (42%)
		TM helix 7	486..511	CDD:320452	10/24 (42%)
Htr2b	XP_006529209.1	7tm_GPCRs	54..413	CDD:475119	109/392 (28%)
		TM helix 1	56..80	CDD:410628	10/23 (43%)
		TM helix 2	89..111	CDD:410628	13/21 (62%)
		TM helix 3	128..150	CDD:410628	12/21 (57%)
		TM helix 4	173..205	CDD:410628	6/31 (19%)
		TM helix 5	230..253	CDD:410628	5/22 (23%)
		TM helix 6	338..360	CDD:410628	9/21 (43%)
		TM helix 7	374..399	CDD:410628	10/24 (42%)