DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT7 and Htr2a

DIOPT Version :10

Sequence 1:NP_524599.1 Gene:5-HT7 / 43669 FlyBaseID:FBgn0004573 Length:564 Species:Drosophila melanogaster
Sequence 2:NP_766400.1 Gene:Htr2a / 15558 MGIID:109521 Length:471 Species:Mus musculus


Alignment Length:508 Identity:133/508 - (26%)
Similarity:230/508 - (45%) Gaps:129/508 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   111 SMNSSPIAIVSYQGITSSNLGD-------------------SNTTLVPLSDTPLLLEEFAAGEFV 156
            |::|.|.:::        .|||                   ||.|:...:.|.|..|.:      
Mouse    10 SLSSIPNSLM--------QLGDDSRLYPNDFNSRDANTSEASNWTIDAENRTNLSCEGY------ 60

  Fly   157 LPPLTSIFV---------SIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVA 212
            ||| |.:.:         :::..:||:.|:.||:||.:||.:.:||:...||.|:|||::|:.:.
Mouse    61 LPP-TCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLG 124

  Fly   213 LLVMPMALLYEVL--EKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRT 275
            .||||:::| .:|  .:|.....||.:|:..|||..||||::|||||:|||:||..|:.:....:
Mouse   125 FLVMPVSML-TILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNS 188

  Fly   276 PRRMMLCVGIVWLAAACISLPPLLILGNEHED---EEGQPICTVC-QNFAYQIYATLGSFYIPLS 336
            ..:..|.:..||..:..||: |:.:.|.:.:.   :||.  |.:. .||.  :..:..:|:|||:
Mouse   189 RTKAFLKIIAVWTISVGISM-PIPVFGLQDDSKVFKEGS--CLLADDNFV--LIGSFVAFFIPLT 248

  Fly   337 VMLFVYYQIFRAARRIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNT 401
            :|:..|:...::.::   |.....:.|......:.....||      :.|:|....||  |:   
Mouse   249 IMVITYFLTIKSLQK---EATLCVSDLSTRAKLSSFSFLPQ------SSLSSEKLFQR--SI--- 299

  Fly   402 SLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVC 466
                               |...|..:|          ::....::.|:||...|||:...|.|.
Mouse   300 -------------------HREPGSYAG----------RRTMQSISNEQKACKVLGIVFFLFVVM 335

  Fly   467 WLPFF---ILALI-RPFETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDF------------- 514
            |.|||   |:|:| :.....:|..:|.::|:|:||.:|.:||::|...|:.:             
Mouse   336 WCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYK 400

  Fly   515 --RKPFQEILY-------FRCSSLNTMMRENYYQDQYGEPPS---QRVMLGDE 555
              |||.|.||.       ::.|.|....::|..:|  .||.:   ..|.||::
Mouse   401 ENRKPLQLILVNTIPTLAYKSSQLQVGQKKNSQED--AEPTANDCSMVTLGNQ 451

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT7NP_524599.1 7tmA_5-HT7 163..518 CDD:320452 104/388 (27%)
TM helix 1 164..190 CDD:320452 9/34 (26%)
TM helix 2 197..223 CDD:320452 12/25 (48%)
TM helix 3 235..265 CDD:320452 18/29 (62%)
TM helix 4 277..299 CDD:320452 6/21 (29%)
TM helix 5 319..348 CDD:320452 8/28 (29%)
TM helix 6 447..477 CDD:320452 15/33 (45%)
TM helix 7 486..511 CDD:320452 9/24 (38%)
Htr2aNP_766400.1 7tmA_5-HT2A 75..391 CDD:341345 102/364 (28%)
TM helix 1 76..102 CDD:341345 9/25 (36%)
TM helix 2 109..135 CDD:341345 12/26 (46%)
TM helix 3 148..178 CDD:341345 18/29 (62%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 172..174 1/1 (100%)
TM helix 4 190..213 CDD:341345 6/23 (26%)
TM helix 5 231..260 CDD:341345 8/30 (27%)
TM helix 6 316..346 CDD:341345 13/29 (45%)
TM helix 7 359..384 CDD:341345 9/24 (38%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 376..380 2/3 (67%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P28223 469..471
Blue background indicates that the domain is not in the aligned region.

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