DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 5-HT7 and Htr1f

DIOPT Version :9

Sequence 1:	NP_001263131.1	Gene:	5-HT7 / 43669	FlyBaseID:	FBgn0004573	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_032336.1	Gene:	Htr1f / 15557	MGIID:	99842	Length:	366	Species:	Mus musculus

Alignment Length:	404	Identity:	153/404 - (37%)
Similarity:	216/404 - (53%)	Gaps:	64/404 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 SDTPLLLEEFAAGEFVLPPLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLA 205
            ||..|..||....   :|  :.|.||:.|..:.|.|...|.||..|:.:.|||..|.|||:.|||
Mouse     7 SDQNLTSEELLNR---MP--SKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLA 66

  Fly   206 LSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEY 270
            ::|..||:||||.:::|.|.|.|..|.:|||||:|.|::|||.|||:|.||::|||.|||..:||
Mouse    67 VTDFLVAVLVMPFSIVYIVRESWIMGQVLCDIWLSVDIICCTCSILHLSAIALDRYRAITDAVEY 131

  Fly   271 GVKRTPRRMMLCVGIVWLAAACISLPPLL--ILGNEHEDEEGQPICTV-CQNFAYQIYATLGSFY 332
            ..|||||...:.:.|||:.:..||:|||.  ..|...:||     |.: ..:....||:|.|:||
Mouse   132 ARKRTPRHAGIMITIVWVISVFISMPPLFWRHQGTSRDDE-----CVIKHDHIVSTIYSTFGAFY 191

  Fly   333 IPLSVMLFVYYQIFRAARRIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSS 397
            |||.::|.:||:|:||||.: ..:::|...:::.|||              .....||    ..|
Mouse   192 IPLVLILILYYKIYRAARTL-YHKRQASRMIKEELNG--------------QVFLESG----EKS 237

  Fly   398 VGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGST------GLLGSP-----HHKKLRFQL---AK 448
            :...|.:|.....||               ..||      ..:.||     |.|..|.|.   .:
Mouse   238 IKLVSTSYMLEKSLS---------------DPSTDFDRIHSTVKSPRSELKHEKSWRRQKISGTR 287

  Fly   449 EKKASTTLGIIMSAFTVCWLPFFILAL-IRPFETMHVPASLSSLFLWLGYANSLLNPIIYATLNR 512
            |:||:||||:|:.||.:||||||:..| :...|...:...:|:...||||.|||:||:||...|.
Mouse   288 ERKAATTLGLILGAFVICWLPFFVKELVVNVCEKCKISEEMSNFLAWLGYLNSLINPLIYTIFNE 352

  Fly   513 DFRKPFQEILYFRC 526
            ||:|.||:::  ||
Mouse   353 DFKKAFQKLV--RC 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_001263131.1	7tm_4	173..>342	CDD:304433	79/171 (46%)
5-HT7	NP_001263131.1	7tm_1	179..507	CDD:278431	131/345 (38%)
Htr1f	NP_032336.1	7tm_4	33..>155	CDD:304433	60/121 (50%)
		7tm_1	41..347	CDD:278431	131/344 (38%)
		Agonist binding. /evidence=ECO:0000250	99..108		4/8 (50%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250	120..122		1/1 (100%)
		Agonist binding. /evidence=ECO:0000250	306..310		3/3 (100%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250	343..347		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42381
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3253
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.900