| Sequence 1: | NP_001263131.1 | Gene: | 5-HT7 / 43669 | FlyBaseID: | FBgn0004573 | Length: | 564 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_034612.1 | Gene: | Htr1b / 15551 | MGIID: | 96274 | Length: | 386 | Species: | Mus musculus |
| Alignment Length: | 419 | Identity: | 142/419 - (33%) |
|---|---|---|---|
| Similarity: | 221/419 - (52%) | Gaps: | 72/419 - (17%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 133 SNTTLVPLSDTPLLLEEFAAGEFV------LPPLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVR 191
Fly 192 KLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAI 256
Fly 257 SVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLILGNEHEDEEGQPICTV-CQNF 320
Fly 321 AYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEEKRAQT--HLQQALNGTGSPSAPQAPPLGH 383
Fly 384 TELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHH--------- 439
Fly 440 ----KKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPF--ETMHVPASLSSLFLWLGYA 498
Fly 499 NSLLNPIIYATLNRDFRKPFQEILYFRCS 527 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| 5-HT7 | NP_001263131.1 | 7tm_4 | 173..>342 | CDD:304433 | 71/169 (42%) |
| 7tm_1 | 179..507 | CDD:278431 | 123/345 (36%) | ||
| Htr1b | NP_034612.1 | 7tmA_5-HT1B_1D | 42..376 | CDD:320455 | 133/378 (35%) |
| TM helix 1 | 47..73 | CDD:320455 | 6/25 (24%) | ||
| TM helix 2 | 80..106 | CDD:320455 | 13/25 (52%) | ||
| TM helix 3 | 118..148 | CDD:320455 | 18/29 (62%) | ||
| Agonist binding. /evidence=ECO:0000250 | 121..130 | 4/8 (50%) | |||
| DRY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250 | 142..144 | 1/1 (100%) | |||
| TM helix 4 | 160..183 | CDD:320455 | 8/24 (33%) | ||
| TM helix 5 | 201..230 | CDD:320455 | 9/28 (32%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 255..278 | 9/63 (14%) | |||
| TM helix 6 | 303..333 | CDD:320455 | 20/29 (69%) | ||
| Agonist binding. /evidence=ECO:0000250 | 323..327 | 3/3 (100%) | |||
| TM helix 7 | 344..369 | CDD:320455 | 13/24 (54%) | ||
| NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250 | 361..365 | 3/3 (100%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S4745 |
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 1 | 1.000 | - | - | otm42381 | |
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R3253 |
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 4 | 3.890 | |||||