Protein Alignment 5-HT7 and Htr1a

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_032334.2
• Gene: Htr1a / 15550
• MGIID: 96273
• Length: 421
• Species: Mus musculus
• Alignment Length: 434
• Identity: 170/434 - (39%)
• Similarity: 238/434 - (54%)
• Gaps: 57/434 - (13%)

  Fly   129 NLGDSNTTLVPLSDTPLLLEEFAAG--EFVLPPLT---SIFVSIVLLIVILGTVVGNVLVCIAVC 188
            :||..|.|...       ||.|..|  :..|..:|   .:..|::|..:|...|:||..|..|:.
Mouse     5 SLGQGNNTTTS-------LEPFGTGGNDTGLSNVTFSYQVITSLLLGTLIFCAVLGNACVVAAIA 62

  Fly   189 MVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNL 253
            :.|.|:...|||:.|||::||.|::||:|||.||:||.||..|.:.||::::.||||||:|||:|
Mouse    63 LERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHL 127

  Fly   254 CAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLILG-NEHEDEEGQPICTVC 317
            |||::|||.|||.|::|..||||||....:.:.||....||:||:  || ...||......||:.
Mouse   128 CAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPM--LGWRTPEDRSNPNECTIS 190

  Fly   318 QNFAYQIYATLGSFYIPLSVMLFVYYQIFRAAR-RI-----VLEEKRAQTHLQQALNGTGSPSAP 376
            ::..|.||:|.|:|||||.:||.:|.:|||||| ||     .:|:|.|.|..     ||.|
Mouse   191 KDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKKGAGTSF-----GTSS---- 246

  Fly   377 QAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSSGG--------------GALAGHGSGGGV 427
             |||...:.....|:|....|..|.::......|....|              |...||......
Mouse   247 -APPPKKSLNGQPGSGDCRRSAENRAVGTPCANGAVRQGEDDATLEVIEVHRVGNSKGHLPLPSE 310

  Fly   428 SGSTGLLGS--------PHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPF--ETM 482
            ||:|..:.:        ....|.:..||:|:|...||||||..|.:|||||||:||:.||  .:.
Mouse   311 SGATSYVPACLERKNERTAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSC 375

  Fly   483 HVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRC 526
            |:|..|.::..||||:||||||:|||..|:||:..|::|:  :|
Mouse   376 HMPELLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKII--KC 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	157/385 (41%)
		TM helix 1	164..190	CDD:320452	8/25 (32%)
		TM helix 2	197..223	CDD:320452	15/25 (60%)
		TM helix 3	235..265	CDD:320452	19/29 (66%)
		TM helix 4	277..299	CDD:320452	8/21 (38%)
		TM helix 5	319..348	CDD:320452	15/28 (54%)
		TM helix 6	447..477	CDD:320452	19/29 (66%)
		TM helix 7	486..511	CDD:320452	14/24 (58%)
Htr1a	NP_032334.2	7tmA_5-HT1A_vertebrates	37..411	CDD:320453	157/385 (41%)
		TM helix 1	38..64	CDD:320453	8/25 (32%)
		TM helix 2	71..97	CDD:320453	15/25 (60%)
		TM helix 3	109..139	CDD:320453	19/29 (66%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	133..135		1/1 (100%)
		TM helix 4	151..173	CDD:320453	8/23 (35%)
		TM helix 5	192..221	CDD:320453	15/28 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	237..268		11/40 (28%)
		TM helix 6	338..368	CDD:320453	19/29 (66%)
		TM helix 7	379..404	CDD:320453	14/24 (58%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	396..400		2/3 (67%)