DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 5-HT7 and Hrh2

DIOPT Version :9

Sequence 1:	NP_001263131.1	Gene:	5-HT7 / 43669	FlyBaseID:	FBgn0004573	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_036013748.1	Gene:	Hrh2 / 15466	MGIID:	108482	Length:	421	Species:	Mus musculus

Alignment Length:	412	Identity:	131/412 - (31%)
Similarity:	191/412 - (46%)	Gaps:	101/412 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 IFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEK 227
            :.:|:||..:|..||.|||:||:||.:.|:||...|..:||||.:||.:.|||||.:.:|::..|
Mouse    19 VTISVVLTTLIFITVAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVMPFSAIYQLSFK 83

  Fly   228 WNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAAC 292
            |:||.:.|:|:.|.||:.||||||||..||:|||.|:|.||.|.|..||.|:.:.:..:|:.:..
Mouse    84 WSFGQVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISIT 148

  Fly   293 ISLPPLLILGNEHEDEEGQP---ICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVL 354
            :|...:.:..|......|..   .|.|..|..|.:...:.:||:||.:|...||:||:.||.
Mouse   149 LSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGMVTFYLPLLIMCVTYYRIFKIARE--- 210

  Fly   355 EEKRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALA 419
                                  ||..:.|                           :||...|
Mouse   211 ----------------------QAKRINH---------------------------ISSWKAA-- 224

  Fly   420 GHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPFE-TMH 483
                                      ..:|.||:.||..:|.||.|||.|:|...:.|... ...
Mouse   225 --------------------------TIREHKATVTLAAVMGAFIVCWFPYFTAFVYRGLRGDDA 263

  Fly   484 VPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRCSSLN---------------TMM 533
            |...:..:.||||||||.||||:|||||||||..:|::.:.:.:|.|               :..
Mouse   264 VNEVVEGIVLWLGYANSALNPILYATLNRDFRMAYQQLFHCKLASHNSHKTSLRLNNSLLSRSQS 328

  Fly   534 RENYYQDQYGEPPSQRVMLGDE 555
            ||..:|::  :|...:|..|.|
Mouse   329 REGRWQEE--KPLKLQVWSGTE 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_001263131.1	7tm_4	173..>342	CDD:304433	70/171 (41%)
5-HT7	NP_001263131.1	7tm_1	179..507	CDD:278431	106/331 (32%)
Hrh2	XP_036013748.1	7tmA_Histamine_H2R	19..298	CDD:320179	121/358 (34%)
		TM helix 1	21..45	CDD:320179	13/23 (57%)
		TM helix 2	54..76	CDD:320179	12/21 (57%)
		TM helix 3	92..114	CDD:320179	13/21 (62%)
		TM helix 4	137..153	CDD:320179	2/15 (13%)
		TM helix 5	179..202	CDD:320179	6/22 (27%)
		TM helix 6	232..254	CDD:320179	10/21 (48%)
		TM helix 7	266..291	CDD:320179	15/24 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910