DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT7 and ADRB1

DIOPT Version :10

Sequence 1:NP_524599.1 Gene:5-HT7 / 43669 FlyBaseID:FBgn0004573 Length:564 Species:Drosophila melanogaster
Sequence 2:NP_000675.1 Gene:ADRB1 / 153 HGNCID:285 Length:477 Species:Homo sapiens


Alignment Length:505 Identity:155/505 - (30%)
Similarity:231/505 - (45%) Gaps:102/505 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    79 LGA---IASASSTGSGSGSGSGSGSGSGSGSYGLASMNSSPIAIVSYQGITSSNLGDSNTTLVPL 140
            :||   :..||..|:.|   |.:....|:.:.....:.:||.|                :.|.|.
Human     1 MGAGVLVLGASEPGNLS---SAAPLPDGAATAARLLVPASPPA----------------SLLPPA 46

  Fly   141 SDTP-LLLEEFAAGEFVLPPLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSL 204
            |::| .|.:::.||           :.:::.:::|..|.|||||.:|:....:|:...|..::||
Human    47 SESPEPLSQQWTAG-----------MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSL 100

  Fly   205 ALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLE 269
            |.:||.:.|||:|......|..:|.:|...|::|.|.||||.||||..||.|::|||||||.|..
Human   101 ASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFR 165

  Fly   270 YG--VKRTPRRMMLCVGIVWLAAACISLPPLLILGNEHEDEEGQ------PICTVCQNFAYQIYA 326
            |.  :.|...|.::|.  ||..:|.:|..|:|:.....|.:|.:      ..|....|.||.|.:
Human   166 YQSLLTRARARGLVCT--VWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIAS 228

  Fly   327 TLGSFYIPLSVMLFVYYQIFRAARRIVLEEKRAQTHLQQALNGTGSPSAPQ-------APPLGHT 384
            ::.|||:||.:|.|||.::||.|::.|   |:..:..::.|.|...|.:|.       |||.|..
Human   229 SVVSFYVPLCIMAFVYLRVFREAQKQV---KKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPP 290

  Fly   385 ELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKE 449
            ..|                        ::...|...:|..|            ..:..|....:|
Human   291 RPA------------------------AAAATAPLANGRAG------------KRRPSRLVALRE 319

  Fly   450 KKASTTLGIIMSAFTVCWLPFFILALIRPFETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDF 514
            :||..||||||..||:||||||:..:::.|....||..|...|.|||||||..|||||.. :.||
Human   320 QKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCR-SPDF 383

  Fly   515 RKPFQEILYFRCSSLNTMMRENYYQD---------QYGEPPSQRVMLGDE 555
            ||.||.:|.  |:......|...:.|         :.|.|||......|:
Human   384 RKAFQGLLC--CARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDD 431

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT7NP_524599.1 7tmA_5-HT7 163..518 CDD:320452 126/369 (34%)
TM helix 1 164..190 CDD:320452 8/25 (32%)
TM helix 2 197..223 CDD:320452 10/25 (40%)
TM helix 3 235..265 CDD:320452 19/29 (66%)
TM helix 4 277..299 CDD:320452 7/21 (33%)
TM helix 5 319..348 CDD:320452 14/28 (50%)
TM helix 6 447..477 CDD:320452 17/29 (59%)
TM helix 7 486..511 CDD:320452 14/24 (58%)
ADRB1NP_000675.1 7tmA_Beta1_AR 59..387 CDD:320624 128/380 (34%)
TM helix 1 60..86 CDD:320624 9/36 (25%)
TM helix 2 93..120 CDD:320624 10/26 (38%)
TM helix 3 131..161 CDD:320624 19/29 (66%)
TM helix 4 175..193 CDD:320624 6/19 (32%)
TM helix 5 221..253 CDD:320624 16/31 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 269..307 9/61 (15%)
TM helix 6 317..347 CDD:320624 17/29 (59%)
TM helix 7 356..381 CDD:320624 14/25 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 403..477 6/29 (21%)
PDZ-Binding 474..477
Blue background indicates that the domain is not in the aligned region.

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