DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 5-HT7 and ADRA2A

DIOPT Version :9

Sequence 1:	NP_001263131.1	Gene:	5-HT7 / 43669	FlyBaseID:	FBgn0004573	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_000672.3	Gene:	ADRA2A / 150	HGNCID:	281	Length:	465	Species:	Homo sapiens

Alignment Length:	474	Identity:	151/474 - (31%)
Similarity:	225/474 - (47%)	Gaps:	91/474 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 PIAIVSY--QGITSSNLGDS--NTTLVPLSDTPLLLEEFAAGEFVLPPLTSIFVSIVLL--IVIL 174
            |:|..|:  .|....:.|::  |.|..|           ..|....|....:.:::|.|  :::|
Human     7 PLAEGSFAPMGSLQPDAGNASWNGTEAP-----------GGGARATPYSLQVTLTLVCLAGLLML 60

  Fly   175 GTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWV 239
            .||.|||||.|||...|.|:.|.|..|||||.:|:.||.||:|.:|..||:..|.||...|:|::
Human    61 LTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYL 125

  Fly   240 SFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLIL--- 301
            :.|||.||:||::|||||:|||.:||:.:||.:||||||:...:..||:.:|.||.|||:.:
Human   126 ALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKK 190

  Fly   302 GNEHEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEEKRAQTHLQQA 366
            |.....:..:|.|.:.....|.|.:.:|||:.|..:|:.||.:|::.|:|        :|.:..:
Human   191 GGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKR--------RTRVPPS 247

  Fly   367 LNGTGSPSAPQAPPLGHTELASSGNGQRHSS--VGNTSLTYSTCGGLSSGGGALAG--------- 420
            ..|   |.|..||| |.||...:|.|...|:  .|..:....|....:.|..|.||
Human   248 RRG---PDAVAAPP-GGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDL 308

  Fly   421 ----------------------HGSGGGVS--------------GSTGL-----------LGSPH 438
                                  .|.|...:              |:||:           :|:..
Human   309 EESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAK 373

  Fly   439 HKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPFETMHVPASLSSLFLWLGYANSLLN 503
            ..:.|.:..:||:.:..|.:::..|.|||.|||....:... ...||.:|...|.|.||.||.||
Human   374 ASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAV-GCSVPRTLFKFFFWFGYCNSSLN 437

  Fly   504 PIIYATLNRDFRKPFQEIL 522
            |:||...|.|||:.|::||
Human   438 PVIYTIFNHDFRRAFKKIL 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_001263131.1	7tm_4	173..>342	CDD:304433	77/171 (45%)
5-HT7	NP_001263131.1	7tm_1	179..507	CDD:278431	127/388 (33%)
ADRA2A	NP_000672.3	7tmA_alpha2A_AR	49..452	CDD:320445	138/415 (33%)
		TM helix 1	51..75	CDD:320445	13/23 (57%)
		TM helix 2	84..106	CDD:320445	12/21 (57%)
		TM helix 3	122..144	CDD:320445	12/21 (57%)
		TM helix 4	167..183	CDD:320445	5/15 (33%)
		TM helix 5	209..232	CDD:320445	8/22 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..368		24/129 (19%)
		PHA03307	244..>389	CDD:223039	27/148 (18%)
		TM helix 6	388..410	CDD:320445	8/21 (38%)
		TM helix 7	420..445	CDD:320445	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3253
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940