Protein Alignment 5-HT7 and TAAR9

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_778227.3
• Gene: TAAR9 / 134860
• HGNCID: 20977
• Length: 348
• Species: Homo sapiens
• Alignment Length: 370
• Identity: 104/370 - (28%)
• Similarity: 156/370 - (42%)
• Gaps: 89/370 - (24%)

  Fly   166 SIVLLIVILGTVV---GNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEK 227
            ||:..::..|.|:   ||:||.||:...::|..|.|:|:.|||.:|..|.:.|||.:.:..|...
Human    33 SILYAVLGFGAVLAAFGNLLVMIAILHFKQLHTPTNFLIASLACADFLVGVTVMPFSTVRSVESC 97

  Fly   228 WNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAAC 292
            |.||...|.....||...|.||:.:||.||||||:|:|.||.|..|.|.....:|:.:.|..:..
Human    98 WYFGDSYCKFHTCFDTSFCFASLFHLCCISVDRYIAVTDPLTYPTKFTVSVSGICIVLSWFFSVT 162

  Fly   293 ISLPPLLILGNEHEDEEGQPICTVC---------QNFAYQIYATLGSFYIPLSVMLFVYYQIFRA 348
            .|. .:...|...|..|...:...|         ||:....:..   |:||...|:|:|.:||..
Human   163 YSF-SIFYTGANEEGIEELVVALTCVGGCQAPLNQNWVLLCFLL---FFIPNVAMVFIYSKIFLV 223

  Fly   349 ARRIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSS 413
            |:           |..:.:..|.|                    |..||
Human   224 AK-----------HQARKIESTAS--------------------QAQSS---------------- 241

  Fly   414 GGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAK-EKKASTTLGIIMSAFTVCWLPFFILALIR 477
                                  |..:|:   ::|| |:||:.||||.|:||.|.|||:.:.|:|.
Human   242 ----------------------SESYKE---RVAKRERKAAKTLGIAMAAFLVSWLPYLVDAVID 281

  Fly   478 PFETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEIL 522
            .:.....|..:..:.:|..|.||.:||:|||...:.|.|..:.|:
Human   282 AYMNFITPPYVYEILVWCVYYNSAMNPLIYAFFYQWFGKAIKLIV 326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	103/364 (28%)
		TM helix 1	164..190	CDD:320452	10/26 (38%)
		TM helix 2	197..223	CDD:320452	10/25 (40%)
		TM helix 3	235..265	CDD:320452	15/29 (52%)
		TM helix 4	277..299	CDD:320452	3/21 (14%)
		TM helix 5	319..348	CDD:320452	9/28 (32%)
		TM helix 6	447..477	CDD:320452	17/30 (57%)
		TM helix 7	486..511	CDD:320452	9/24 (38%)
TAAR9	NP_778227.3	7tmA_TAAR6_8_9	33..322	CDD:320439	103/364 (28%)
		TM helix 1	34..60	CDD:320439	9/25 (36%)
		TM helix 2	67..93	CDD:320439	10/25 (40%)
		TM helix 3	105..135	CDD:320439	15/29 (52%)
		TM helix 4	147..170	CDD:320439	3/23 (13%)
		Extracellular Loop 2 (ECL2). /evidence=ECO:0000250|UniProtKB:Q5QD04	174..187		2/12 (17%)
		TM helix 5	194..223	CDD:320439	10/31 (32%)
		TM helix 6	251..281	CDD:320439	16/29 (55%)
		TM helix 7	290..315	CDD:320439	9/24 (38%)