Protein Alignment 5-HT7 and LOC1278365

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_061513053.1
• Gene: LOC1278365 / 1278365
• VectorBaseID: AGAMI1_001113
• Length: 701
• Species: Anopheles gambiae
• Alignment Length: 583
• Identity: 193/583 - (33%)
• Similarity: 276/583 - (47%)
• Gaps: 110/583 - (18%)

  Fly    42 LSSWIAYAAGKATVPAPL-----------VEGETESATSQDFNSSSAFLGAIASASSTGSGSGSG 95
            ||:.::...|.||. |||           ..|||....:|...|:  :.....|...|...|.:.
Mosquito   122 LSTALSSPYGTATT-APLDGFTSEATLPTTHGETVHNLTQSLLSN--YTATDYSVDITNGSSLAP 183

  Fly    96 SGSGSGSGSGSYGL--------------ASMNSSPIAIVSY-----QGITSSNLGDSNTTLVPLS 141
            ..|....||.|.||              |..|.:...:::|     .|...::....|.|:.|..
Mosquito   184 DASTLARGSSSAGLSLSLPDLLEEDELMALWNCTNCFLLNYGAAAAAGANGTSKFYGNGTVDPRD 248

  Fly   142 DTPLLLEEFAAGEFVLPPLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLAL 206
            ..|...::..|.|..:..:..|..:|||.||||.||:|||.|..|:.:.|.|:...|:|::|||:
Mosquito   249 VLPTGEDDILASETTIYLIRVIATAIVLGIVILATVIGNVFVIAAILLERNLQSVANHLILSLAV 313

  Fly   207 SDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYG 271
            :||.||.||||:..:|||.::|..|..|||:|.|.||||||||||:|.||::|||.|:| .::|.
Mosquito   314 ADLLVACLVMPLGAVYEVSKEWRLGADLCDMWTSSDVLCCTASILHLVAIALDRYWAVT-DIDYA 377

  Fly   272 VKRTPRRMMLCVGIVWLAAACISLPPLLILGN-EHEDEEGQPI-CTVCQNFAYQIYATLGSFYIP 334
            .:||.||:...:.|:|..:..:|:.|||...: |.|....|.: |.|.|:..|||:||..|||:|
Mosquito   378 HQRTARRIGYMIIIIWTLSVLVSIAPLLGWKDPEWETRVYQDLQCIVSQDVGYQIFATASSFYVP 442

  Fly   335 LSVMLFVYYQIFRAAR-RIVLEEKRAQTH--------------------------------LQQA 366
            |.|:||:|::||.||| ||...::.||||                                :...
Mosquito   443 LLVILFLYWRIFLAARKRIRRRQQAAQTHPEPLAKASCMALTSIGFRWKVTATQTASGGGMIANV 507

  Fly   367 LNGTGSPSAPQAPPLGH------------TELASSGNGQRHSSVGN---------------TSLT 404
            ..|:|..:|.....:|.            |.::|:.......|:||               .|:.
Mosquito   508 AGGSGGIAAAVVAVIGRPLPTISETTTAFTNVSSANTSPEKGSLGNGIERDRIEIDPPTADISMA 572

  Fly   405 YSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQL--AKEKKASTTLGIIMSAFTVCW 467
            |.:        |..|...|.....||:||..   .||.:...  .:|:||:.||.||..||..||
Mosquito   573 YPS--------GNQASCSSTTRPPGSSGLAS---RKKTQSSTDSKRERKAAKTLAIITGAFVCCW 626

  Fly   468 LPFFILALIRPFET-MHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRCSSL 529
            |||||:|::.|..| .::...::|:.|||||.||.||||||...:.:||..|:.||..|..||
Mosquito   627 LPFFIIAILLPTCTSCNISPLITSVCLWLGYFNSTLNPIIYTIFSPEFRHAFKRILCGRRYSL 689

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	155/419 (37%)
		TM helix 1	164..190	CDD:320452	14/25 (56%)
		TM helix 2	197..223	CDD:320452	13/25 (52%)
		TM helix 3	235..265	CDD:320452	21/29 (72%)
		TM helix 4	277..299	CDD:320452	6/21 (29%)
		TM helix 5	319..348	CDD:320452	16/28 (57%)
		TM helix 6	447..477	CDD:320452	17/29 (59%)
		TM helix 7	486..511	CDD:320452	14/24 (58%)
LOC1278365	XP_061513053.1	None