Protein Alignment 5-HT7 and LOC1269968

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_061499186.1
• Gene: LOC1269968 / 1269968
• VectorBaseID: AGAMI1_010361
• Length: 587
• Species: Anopheles gambiae
• Alignment Length: 563
• Identity: 174/563 - (30%)
• Similarity: 251/563 - (44%)
• Gaps: 162/563 - (28%)

  Fly   105 GSYGLAS-MNSSPIAIVSYQGITSSNLGDSNTTLVPLSDTPLLLEEFAAGEFVLPPLTSIFVSIV 168
            ||.|..: .|.|..|..:     :::||....::...:|.||       .:.::..:|    |:|
Mosquito    44 GSIGNETFFNESANAFAN-----TTDLGPVPASINGTADEPL-------ADVIVMAIT----SLV 92

  Fly   169 LLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPL 233
            |.::||.||:|||.|..|:.:.|.|:...|||:.|||::||.||.||||:..:||:...|..||.
Mosquito    93 LGLMILVTVIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISRGWILGPE 157

  Fly   234 LCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPL 298
            |||||.|.||||||||||:|.||:.|||.|:|. ::|...||.||:...:.:||.|:..:||.|.
Mosquito   158 LCDIWTSCDVLCCTASILHLVAIATDRYWAVTN-IDYIHSRTSRRVFTMIFLVWFASVIVSLAPQ 221

  Fly   299 LILGN-EHEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIV--------- 353
            ....: |:.....|..|.|.||.|||::||..:||:||.|:|.:|::|::.|||.:
Mosquito   222 FGWKDPEYLQRIEQQKCMVSQNIAYQVFATCCTFYVPLFVILVLYWKIYQTARRRIHRRGPKIPA 286

  Fly   354 ----------------------------------------------------LEEKRAQTHLQQA 366
                                                                .|:..|....::.
Mosquito   287 TPNSSNQEETPKPKSKIRFHLKKKFTNPTKSAVSSLGLVEGNSTNTVNTVEDTEDSTANAADRKG 351

  Fly   367 LNGTGSPSAPQAPPLG------------HTELA---------SSGNGQRHSSVGNTSLTYSTCGG 410
            |..|.|.......|||            |.:||         ::.|..|..|.|.||
Mosquito   352 LETTFSGDEGNGTPLGNNQIPTVSYEVTHQQLAQAAGCSESNNNNNPGRTGSAGKTS-------- 408

  Fly   411 LSSGGGALAG--------HGS---------------------------------GGGVSGSTG-- 432
            .|..||.|.|        |.|                                 |.|:.|:.|
Mosquito   409 PSGNGGTLPGSTYPVQAVHASSPLLPPQHQHHNAATAAKQPAGTPTAHLTPGSAGSGLQGAGGGS 473

  Fly   433 ---LLGSPH------HKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPF-ETMHVPAS 487
               :..:|:      .:|...:..:|:||:.||.||..||.|||||||:.||:.|. |:..:..:
Mosquito   474 TLNIASTPNPQAQVSKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFLTALLLPLCESCSINDT 538

  Fly   488 LSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRCSSLN 530
            ::||||||||.||.|||:||...:.:||:.|:.||:....|.|
Mosquito   539 VASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRILFGTHRSAN 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	157/490 (32%)
		TM helix 1	164..190	CDD:320452	12/25 (48%)
		TM helix 2	197..223	CDD:320452	14/25 (56%)
		TM helix 3	235..265	CDD:320452	22/29 (76%)
		TM helix 4	277..299	CDD:320452	8/21 (38%)
		TM helix 5	319..348	CDD:320452	14/28 (50%)
		TM helix 6	447..477	CDD:320452	18/29 (62%)
		TM helix 7	486..511	CDD:320452	15/24 (63%)
LOC1269968	XP_061499186.1	None