Protein Alignment 5-HT7 and 5-HT2A

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_061500179.1
• Gene: 5-HT2A / 1269329
• VectorBaseID: AGAMI1_010455
• Length: 825
• Species: Anopheles gambiae
• Alignment Length: 596
• Identity: 165/596 - (27%)
• Similarity: 254/596 - (42%)
• Gaps: 130/596 - (21%)

  Fly    56 PAPLVEGETESATSQDFNSSSAFLGAIASASSTGSGSGSGSGSGSGSGSGSYGLASMN-SSPI-- 117
            |.|....:|..|......|.....|.:::.|..        .:||...|.::.|.|:: ..||
Mosquito   205 PTPAQPSQTARAVPGPVQSVRLVCGNVSTESPL--------AAGSLFESDAFELVSVSLLEPIQC 261

  Fly   118 --------AIVSYQGITSSNLGDSNTTLVPLSDTPLLLEEFAAGEFVLPPLTSIFVSIVLLIVIL 174
                    |:||...:..:. ..:...|...:.|.||.|..|.|:.........|:.::|.|...
Mosquito   262 WMNVELRNALVSPTWLNGAE-HHAVAALAGWNQTQLLGELPAGGDTAPGRYEWSFLFVILFIFAG 325

  Fly   175 GTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWV 239
            |  :||:|||:||.:.|||:...||.|:|||::||.|:|.|||:..:...|..|.||...|:|:|
Mosquito   326 G--LGNILVCLAVALDRKLQNVTNYFLLSLAIADLLVSLFVMPLGAIPGFLGYWPFGVTWCNIYV 388

  Fly   240 SFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLILG-- 302
            :.|||.|:||||::|.||:.|||.|..||......|.|...:.:.:|||.|..:| ..:.:||
Mosquito   389 TCDVLACSASILHMCFISLGRYLGIRNPLGSRHHSTKRLTGIKIALVWLLAMLVS-SSITVLGMI 452

  Fly   303 NEHEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVY---YQIFRAARRIVLEEKRAQTHLQ 364
            |::....|...| |..|.|:.::.:|.:||||:.:|:..|   .|:.|...|.:  |:..:..|.
Mosquito   453 NQNNIMPGPNEC-VINNRAFFVFGSLVAFYIPMVMMVVTYALTVQLLRKKARFL--EQHPEGELF 514

  Fly   365 QALNG-------------TGSPSAPQA----------------------PP-------LGHTEL- 386
            :.|.|             .||.::.:|                      ||       .||:.|
Mosquito   515 RRLGGRLASSKHSNNSQSDGSSTSNKAVEMRKFTVNNNKQPAYGQHDSSPPSSLPSVAAGHSALP 579

  Fly   387 -----ASSGNGQRHSSVGNT--SLTYSTCGGLSSGGGALAGHGS--------------------- 423
                 .::|.|:..|.:.:.  |:::...|..:.|...:||..|
Mosquito   580 WRWHGTTAGTGKMDSRMSSIKGSMSHPHLGYSNGGNRTMAGKRSRTVCDQGTQTPDSIERETRRQ 644

  Fly   424 -------------GGGVSGSTGLLGSPHHKKLRFQ-LAKEKKASTTLGIIMSAFTVCWLPFFILA 474
                         ...::.:...|||.....|... :|.|:||:..||::...|..||.|||||.
Mosquito   645 KFCSFRIHLNSVPTPAINFNLKFLGSKKRTNLSANAVATEQKATKVLGLVFFTFVFCWAPFFILN 709

  Fly   475 LI-RPFETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRCSSLNTMMRENYY 538
            :| ..:....||..:.|:.|||||.:|.:|||||...|:.||..|..:|..||
Mosquito   710 IIFAAWPEAKVPERIVSICLWLGYVSSTINPIIYTIFNKTFRAAFIRLLRCRC------------ 762

  Fly   539 QDQYGEPPSQR 549
             ::.|.||..|
Mosquito   763 -ERSGRPPRYR 772

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	133/445 (30%)
		TM helix 1	164..190	CDD:320452	11/25 (44%)
		TM helix 2	197..223	CDD:320452	13/25 (52%)
		TM helix 3	235..265	CDD:320452	17/29 (59%)
		TM helix 4	277..299	CDD:320452	6/21 (29%)
		TM helix 5	319..348	CDD:320452	10/31 (32%)
		TM helix 6	447..477	CDD:320452	15/30 (50%)
		TM helix 7	486..511	CDD:320452	12/24 (50%)
5-HT2A	XP_061500179.1	None