Protein Alignment 5-HT7 and Adra2b

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_033763.3
• Gene: Adra2b / 11552
• MGIID: 87935
• Length: 448
• Species: Mus musculus
• Alignment Length: 437
• Identity: 144/437 - (32%)
• Similarity: 212/437 - (48%)
• Gaps: 91/437 - (20%)

  Fly   165 VSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWN 229
            ::..:..:||.|:.||.||.:||...|.||.|.|..|||||.:|:.||.|::|.:|..|:|..|.
Mouse    15 IASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWY 79

  Fly   230 FGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACIS 294
            |....|:::::.|||.||:||::|||||:|||.|:::.|||..||||||:...:..|||.||.||
Mouse    80 FWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVIS 144

  Fly   295 LPPLLILGNEHEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEEKRA 359
            ||||:..|::..:..|.|.|.:.|...|.:.:::|||:.|..:|:.||.:|:..|:|
Mouse   145 LPPLIYKGDQRPEPHGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKR-------- 201

  Fly   360 QTHLQ--QALNGTGS-------------PSAPQAPPLGHTELASSG--NGQ----RHSSVGNT-- 401
             :|.:  .|..|:|.             |::.:.|.| .:.|:|.|  ||.    |....|.|
Mouse   202 -SHCRGLGAKRGSGEGESKKPHPAAGGVPASAKVPTL-VSPLSSVGEANGHPKPPREKEEGETPE 264

  Fly   402 ------------SLTYSTCGGLSSGGGALAGHGS------------------------------- 423
                        :|..|.........||.|..|:
Mouse   265 DPEARALPPNWSALPRSVQDQKKGTSGATAEKGAEEDEEEVEECEPQTLPASPASVFNPPLQQPQ 329

  Fly   424 --------GGGV--SGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFI---LAL 475
                    .|.|  |.:.|:......:: |.||::||:.:..|.:::..|.|||.|||.   |..
Mouse   330 TSRVLATLRGQVLLSKNVGVASGQWWRR-RTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGA 393

  Fly   476 IRPFETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEIL 522
            |.| :...||..|...|.|:||.||.|||:||...|:|||:.|:.||
Mouse   394 ICP-QHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRIL 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	141/431 (33%)
		TM helix 1	164..190	CDD:320452	9/24 (38%)
		TM helix 2	197..223	CDD:320452	12/25 (48%)
		TM helix 3	235..265	CDD:320452	17/29 (59%)
		TM helix 4	277..299	CDD:320452	12/21 (57%)
		TM helix 5	319..348	CDD:320452	9/28 (32%)
		TM helix 6	447..477	CDD:320452	11/32 (34%)
		TM helix 7	486..511	CDD:320452	12/24 (50%)
Adra2b	NP_033763.3	TM helix 3	85..115	CDD:320444	17/29 (59%)
		TM helix 4	127..150	CDD:320444	13/22 (59%)
		TM helix 5	169..198	CDD:320444	9/28 (32%)
		TM helix 6	362..392	CDD:320444	10/29 (34%)
		TM helix 7	403..428	CDD:320444	12/24 (50%)
		7tmA_alpha2B_AR	7..435	CDD:320444	141/431 (33%)
		TM helix 1	14..40	CDD:320444	9/24 (38%)
		TM helix 2	47..73	CDD:320444	12/25 (48%)