Protein Alignment 5-HT7 and Adra1d

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_038488.4
• Gene: Adra1d / 11550
• MGIID: 106673
• Length: 562
• Species: Mus musculus
• Alignment Length: 494
• Identity: 143/494 - (28%)
• Similarity: 230/494 - (46%)
• Gaps: 72/494 - (14%)

  Fly    75 SSAFLGAIASASSTGSGSGSGSGSGSGSGSGSYGLASMNSSPIAIVSYQGITSSNLGDSNTTLVP 139
            |..|.|..||:|:.|||:|.|:|:....|....|:.........:    |..|.....|:|....
Mouse     8 SVTFEGPRASSSTGGSGAGGGAGTVGPEGPAVGGVPGATGGSAVV----GTGSGEDNQSSTAEAG 68

  Fly   140 LSDTPLLLEEFAAGEFVLPPLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSL 204
            .:.:..:....|.|..|: ....:.|.:.|...||..|.||:||.::|...|.|:...||.:|:|
Mouse    69 AAASGEVNGSAAVGGLVV-SAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNL 132

  Fly   205 ALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLE 269
            |::||.::..|:|.:...|||..|.||...||:|.:.||||||||||:||.||||||:.:...|:
Mouse   133 AVADLLLSAAVLPFSATMEVLGFWAFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLK 197

  Fly   270 YGVKRTPRRMMLCVGIVWLAAACISLPPLLILGNEHEDEEGQPICTVCQNFAYQIYATLGSFYIP 334
            |....|.|:....:.::|..|..:|:.||  ||.:......:..|.:.:...|.|::::.|||:|
Mouse   198 YPAIMTERKAAAILALLWAVALVVSVGPL--LGWKEPVPPDERFCGITEEVGYAIFSSVCSFYLP 260

  Fly   335 LSVMLFVYYQIFRAARRIV--LEE-------KRAQTHLQQALNGTGSPSAPQAPPLGHTELASSG 390
            ::|::.:|.:::..||...  ||.       |.::..|:....|..:              ::.|
Mouse   261 MAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRIHCRGAAT--------------SAKG 311

  Fly   391 NGQRHSSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTT 455
            |....||.|:|                               |..|...:.|:|  ::||||:.|
Mouse   312 NPGTQSSKGHT-------------------------------LRSSLSVRLLKF--SREKKAAKT 343

  Fly   456 LGIIMSAFTVCWLP-FFILALIRPFETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQ 519
            |.|::..|.:||.| ||:|.|...|..:.....:..:..||||.||.:||:||...:|:|::.|.
Mouse   344 LAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFL 408

  Fly   520 EILYFRCSSLNTMMRENY---YQDQYGEP-----PSQRV 550
            .:|..:|......:...|   ::...|:|     ||.|:
Mouse   409 RLLRCQCRRRRRRLWRVYGHHWRASTGDPRSDCAPSPRI 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	113/364 (31%)
		TM helix 1	164..190	CDD:320452	10/25 (40%)
		TM helix 2	197..223	CDD:320452	9/25 (36%)
		TM helix 3	235..265	CDD:320452	21/29 (72%)
		TM helix 4	277..299	CDD:320452	5/21 (24%)
		TM helix 5	319..348	CDD:320452	8/28 (29%)
		TM helix 6	447..477	CDD:320452	15/30 (50%)
		TM helix 7	486..511	CDD:320452	10/24 (42%)
Adra1d	NP_038488.4	7tm_GPCRs	91..407	CDD:475119	113/364 (31%)
		TM helix 1	93..117	CDD:410628	10/23 (43%)
		TM helix 2	126..148	CDD:410628	9/21 (43%)
		TM helix 3	164..186	CDD:410628	15/21 (71%)
		TM helix 4	209..225	CDD:410628	3/15 (20%)
		TM helix 5	246..269	CDD:410628	7/22 (32%)
		TM helix 6	341..363	CDD:410628	9/21 (43%)
		TM helix 7	375..400	CDD:410628	10/24 (42%)