Protein Alignment 5-HT7 and LOC11175717

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_061507703.1
• Gene: LOC11175717 / 11175717
• VectorBaseID: AGAMI1_012729
• Length: 809
• Species: Anopheles gambiae
• Alignment Length: 787
• Identity: 187/787 - (23%)
• Similarity: 273/787 - (34%)
• Gaps: 321/787 - (40%)

  Fly    19 NH------RTQGNHQKLISTATLTLFVLFLSSWIAYAAGKATVPAPLVEGETESATSQDFNSSSA 77
            ||      .|..|...||.:..||.....:.|..|.||...:..:.:|.|.:.:..:...|.|..
Mosquito    50 NHTHAAVPTTAANFFNLIDSLELTTRSRSVPSLAASAASIGSAASHVVGGRSRTLAALSANVSEL 114

  Fly    78 FLGAIASASSTGSGSGSGSGSGSGSGSGSYGLASMNSSPIAIVSYQGITSSNLGDSNTTLVPLS- 141
            .                .:|||.......|........|:|..:   ||:.::|  |||:.|.:
Mosquito   115 V----------------EAGSGRAYDPALYDDGRSLYDPLAAAT---ITTVSIG--NTTVQPATV 158

  Fly   142 ---------------------------------------DTPLLLEEFAAGEFVLPPLTSIFVSI 167
                                                   :.|..::|    .|::.......|.|
Mosquito   159 FGPRPGVTDGSVLIGSGTSAATTLVVDLVGTVDPTARQLELPSAMDE----HFLIANWQDCVVVI 219

  Fly   168 VLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGP 232
            :..::|:.||:||.||.::|...|:||...|..::|||::|..|.:.|||.|:...::..|..|.
Mosquito   220 LFCLLIVVTVIGNTLVILSVITTRRLRTVTNCFVMSLAVADWLVGIFVMPPAVAVHLMGSWQLGW 284

  Fly   233 LLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRM-MLCVGIVWLAAACISLP 296
            :|||||:|.|||.||||||:|||||:|||||:|:||.|..:|..:|: :|.:.:||:.|..|:.|
Mosquito   285 ILCDIWISLDVLLCTASILSLCAISIDRYLAVTQPLNYSRRRRSKRLALLMILVVWVLALAITCP 349

  Fly   297 PLL---ILGNEHEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVY---------------- 342
            |:|   ..|....|:     |...||..|.:::.:|||:||::||::||
Mosquito   350 PILGWYEPGRRELDQ-----CRYNQNEGYVVFSAMGSFFIPMTVMVYVYVRISCVVASRHDKMTE 409

  Fly   343 YQIFRAARR---------------IVLEEKRAQ-------------------------------- 360
            .::.:.:.|               |.|..||.:
Mosquito   410 IEVHKKSHRVREPEEDGYQSEQDPIPLSPKRKRSSSQLSTATTTYVAQLGPMLDEGVGAGQPPKP 474

  Fly   361 ----------------------------THLQQALNGTGSP----SAPQAPPLGH---------- 383
                                        |.|..|.||||.|    |...|...||
Mosquito   475 AGKRNNHKHGHYELMDLNTTGGSTQSQTTILAAAGNGTGGPTGDTSTASAAAEGHHHHQEQLRQR 539

  Fly   384 -----------------------------------------------------TELASSGN---- 391
                                                                 .||.||||
Mosquito   540 TYDDGTSLDAIVDDPAVVLAGPGSGSTESNTSTAATTAAPVSASVNYNKLPSTAELWSSGNSVFN 604

  Fly   392 ----------------------------------------------------------GQRHSSV 398
                                                                      |.|.::.
Mosquito   605 QQSHKPQSHSMASFAGAAGAGSPPNHSQHFHHHHHHHHHHHHHHHEGRPTAALAAATGGLRRNNT 669

  Fly   399 GNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLA---KEKKASTTLGIIM 460
            .|||:|.|||..:...||...|:..            ..|.|.|..:::   :|.|.:.||.|::
Mosquito   670 VNTSITTSTCSSVQLVGGRTGGNNI------------RIHQKSLSSRISSMKRENKTTRTLSIVV 722

  Fly   461 SAFTVCWLPFFILALIRPF--ETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEIL- 522
            ..|..|||||||..:|.||  :...|| .||..|.|||:.||.:||.|||..:.|||..|..:.
Mosquito   723 GGFIACWLPFFIHYIITPFLPKDWTVP-KLSEFFTWLGWINSAINPFIYAFYSVDFRAAFWRLTL 786

  Fly   523 --YFRCS 527
              :||.|
Mosquito   787 RRFFRNS 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	151/583 (26%)
		TM helix 1	164..190	CDD:320452	10/25 (40%)
		TM helix 2	197..223	CDD:320452	10/25 (40%)
		TM helix 3	235..265	CDD:320452	24/29 (83%)
		TM helix 4	277..299	CDD:320452	8/22 (36%)
		TM helix 5	319..348	CDD:320452	11/44 (25%)
		TM helix 6	447..477	CDD:320452	13/32 (41%)
		TM helix 7	486..511	CDD:320452	13/24 (54%)
LOC11175717	XP_061507703.1	None