Protein Alignment 5-HT7 and adra1d

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_002935531.2
• Gene: adra1d / 100495969
• XenbaseID: XB-GENE-6050827
• Length: 500
• Species: Xenopus tropicalis
• Alignment Length: 415
• Identity: 128/415 - (30%)
• Similarity: 210/415 - (50%)
• Gaps: 89/415 - (21%)

  Fly   131 GDSNTTLVPLSDTPLLLEEFAAGEFV-----LPPLTSIFVSIVLLIVILGTVVGNVLVCIAVCMV 190
            ||::|            |:.|.|..:     ||.|:   |.|||.:.||..:|||::|.::|...
 Frog    21 GDNDT------------EDHANGTSLSLALDLPALS---VGIVLAVFILFAIVGNIMVILSVACN 70

  Fly   191 RKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVSFDVLCCTASILNLCA 255
            |:|:...||.:|:||::||.::..|:|.:...|||..|.||.:.||||.:.|||||||||::||.
 Frog    71 RQLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTASIMSLCV 135

  Fly   256 ISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLILGNEHEDEEGQPICTVCQNF 320
            ||:|||:.:...|:|....|.::.::.:.::||::..||:.||  ||.:.........|::.:..
 Frog   136 ISIDRYVGVKYSLKYPTIMTEKKAVVILILLWLSSMVISIGPL--LGWKEPPPPDDSKCSITEEP 198

  Fly   321 AYQIYATLGSFYIPLSVMLFVYYQIFRAARRI-------VLEEKR------AQTHLQQALNGTGS 372
            .|.::::|.|||:||.|:|.:|::::..|||.       |.:|:.      .:.|.:..|..:.|
 Frog   199 GYALFSSLFSFYLPLLVILVMYFRVYIVARRTTKSLEAGVKKERNKSMEVVLRIHCRSVLEESSS 263

  Fly   373 PSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSP 437
                           |:.|.:.|:...:.|:
 Frog   264 ---------------STRNHKGHTFRSSLSV---------------------------------- 279

  Fly   438 HHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFF-ILALIRPFETMHVPASLSSLFLWLGYANSL 501
              :.|:|  ::||||:.||.|::..|.:|||||| ||.|...|..:....|:..:..||||.||.
 Frog   280 --RLLKF--SREKKAAKTLAIVVGVFILCWLPFFLILPLGSFFPALKPTDSVFKVIFWLGYFNSC 340

  Fly   502 LNPIIYATLNRDFRKPFQEILYFRC 526
            :|||||...:::|::.|..||..:|
 Frog   341 VNPIIYPCSSKEFKRAFIRILKCQC 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	115/368 (31%)
		TM helix 1	164..190	CDD:320452	11/25 (44%)
		TM helix 2	197..223	CDD:320452	9/25 (36%)
		TM helix 3	235..265	CDD:320452	20/29 (69%)
		TM helix 4	277..299	CDD:320452	5/21 (24%)
		TM helix 5	319..348	CDD:320452	10/28 (36%)
		TM helix 6	447..477	CDD:320452	17/30 (57%)
		TM helix 7	486..511	CDD:320452	12/24 (50%)
adra1d	XP_002935531.2	7tmA_alpha1D_AR	43..357	CDD:320450	116/371 (31%)
		TM helix 1	44..70	CDD:320450	11/28 (39%)
		TM helix 2	77..103	CDD:320450	9/25 (36%)
		TM helix 3	115..145	CDD:320450	20/29 (69%)
		TM helix 4	157..180	CDD:320450	6/24 (25%)
		TM helix 5	197..226	CDD:320450	10/28 (36%)
		TM helix 6	285..315	CDD:320450	16/29 (55%)
		TM helix 7	325..350	CDD:320450	12/24 (50%)