Protein Alignment 5-HT7 and htr1b

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_002936251.2
• Gene: htr1b / 100495915
• XenbaseID: XB-GENE-988006
• Length: 385
• Species: Xenopus tropicalis
• Alignment Length: 374
• Identity: 138/374 - (36%)
• Similarity: 219/374 - (58%)
• Gaps: 38/374 - (10%)

  Fly   161 TSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVL 225
            :.|.::::|.::.|.|::.|..|...|...|||..|.|||:.|||.:||.|::||:|:|::|.|.
 Frog    44 SKIILTVILALITLATLLSNAFVITTVYQTRKLHTPANYLIASLAFTDLLVSILVLPIAIVYTVT 108

  Fly   226 EKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAA 290
            .||..|.::||:|:|.|:.|||||||:||.|::|||.|||..:||..||||:|.::.:.:||:.:
 Frog   109 GKWTLGQIICDMWLSSDITCCTASILHLCVIALDRYWAITDAVEYTKKRTPKRAVVMIALVWVFS 173

  Fly   291 ACISLPPLLILGNEHEDEEGQPICTV-CQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVL 354
            ..||:|||....::.|:   ..:|.| ..:..|.:|:|:|:||||..:::.:|.:|:..||..:|
 Frog   174 ISISMPPLFWRQSKAEE---IAVCAVNTDHILYTVYSTVGAFYIPTLLLIALYGRIYVEARSRIL 235

  Fly   355 EE--KRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGA 417
            ::  |.....|.:|...|.||.:                    |||.:|:   |....:.|..|:
 Frog   236 KQSPKTTGKRLTKAHLITDSPGS--------------------SSVSSTN---SRTLEMPSDAGS 277

  Fly   418 LAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPF--E 480
            .. :.:...|..|..||     :|.:...|:|:||:.|||:|:.|:.||||||||::|:.|.  :
 Frog   278 PV-YLNQVKVKVSDALL-----EKKKIMAARERKATKTLGVILGAYIVCWLPFFIISLVMPICKD 336

  Fly   481 TMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEIL-YFRCSS 528
            ......::...|.||||.|||:|||||...|.||::.|.::: .|:|||
 Frog   337 ACWFHPAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLINRFKCSS 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	133/359 (37%)
		TM helix 1	164..190	CDD:320452	6/25 (24%)
		TM helix 2	197..223	CDD:320452	13/25 (52%)
		TM helix 3	235..265	CDD:320452	19/29 (66%)
		TM helix 4	277..299	CDD:320452	7/21 (33%)
		TM helix 5	319..348	CDD:320452	10/28 (36%)
		TM helix 6	447..477	CDD:320452	18/29 (62%)
		TM helix 7	486..511	CDD:320452	13/24 (54%)
htr1b	XP_002936251.2	7tmA_5-HT1B_1D	42..374	CDD:320455	133/361 (37%)
		TM helix 1	47..73	CDD:320455	6/25 (24%)
		TM helix 2	80..106	CDD:320455	13/25 (52%)
		TM helix 3	118..148	CDD:320455	19/29 (66%)
		TM helix 4	160..183	CDD:320455	8/22 (36%)
		TM helix 5	200..229	CDD:320455	10/28 (36%)
		TM helix 6	301..331	CDD:320455	18/29 (62%)
		TM helix 7	342..367	CDD:320455	13/24 (54%)