DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 5-HT7 and htr1b

DIOPT Version :9

Sequence 1:	NP_001263131.1	Gene:	5-HT7 / 43669	FlyBaseID:	FBgn0004573	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_002936251.2	Gene:	htr1b / 100495915	XenbaseID:	XB-GENE-988006	Length:	385	Species:	Xenopus tropicalis

Alignment Length:	374	Identity:	138/374 - (36%)
Similarity:	219/374 - (58%)	Gaps:	38/374 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 TSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVL 225
            :.|.::::|.::.|.|::.|..|...|...|||..|.|||:.|||.:||.|::||:|:|::|.|.
Frog    44 SKIILTVILALITLATLLSNAFVITTVYQTRKLHTPANYLIASLAFTDLLVSILVLPIAIVYTVT 108

  Fly   226 EKWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAA 290
            .||..|.::||:|:|.|:.|||||||:||.|::|||.|||..:||..||||:|.::.:.:||:.:
Frog   109 GKWTLGQIICDMWLSSDITCCTASILHLCVIALDRYWAITDAVEYTKKRTPKRAVVMIALVWVFS 173

  Fly   291 ACISLPPLLILGNEHEDEEGQPICTV-CQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVL 354
            ..||:|||....::.|:   ..:|.| ..:..|.:|:|:|:||||..:::.:|.:|:..||..:|
Frog   174 ISISMPPLFWRQSKAEE---IAVCAVNTDHILYTVYSTVGAFYIPTLLLIALYGRIYVEARSRIL 235

  Fly   355 EE--KRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGA 417
            ::  |.....|.:|...|.||.:                    |||.:|:   |....:.|..|:
Frog   236 KQSPKTTGKRLTKAHLITDSPGS--------------------SSVSSTN---SRTLEMPSDAGS 277

  Fly   418 LAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPF--E 480
            .. :.:...|..|..||     :|.:...|:|:||:.|||:|:.|:.||||||||::|:.|.  :
Frog   278 PV-YLNQVKVKVSDALL-----EKKKIMAARERKATKTLGVILGAYIVCWLPFFIISLVMPICKD 336

  Fly   481 TMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEIL-YFRCSS 528
            ......::...|.||||.|||:|||||...|.||::.|.::: .|:|||
Frog   337 ACWFHPAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLINRFKCSS 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_001263131.1	7tm_4	173..>342	CDD:304433	73/169 (43%)
5-HT7	NP_001263131.1	7tm_1	179..507	CDD:278431	124/332 (37%)
htr1b	XP_002936251.2	7tmA_5-HT1B_1D	42..374	CDD:320455	133/361 (37%)
		TM helix 1	47..73	CDD:320455	6/25 (24%)
		TM helix 2	80..106	CDD:320455	13/25 (52%)
		TM helix 3	118..148	CDD:320455	19/29 (66%)
		TM helix 4	160..183	CDD:320455	8/22 (36%)
		TM helix 5	200..229	CDD:320455	10/28 (36%)
		TM helix 6	301..331	CDD:320455	18/29 (62%)
		TM helix 7	342..367	CDD:320455	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3253
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940