DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 5-HT7 and htr7

DIOPT Version :9

Sequence 1:	NP_001263131.1	Gene:	5-HT7 / 43669	FlyBaseID:	FBgn0004573	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_031762460.1	Gene:	htr7 / 100494876	XenbaseID:	XB-GENE-1013674	Length:	440	Species:	Xenopus tropicalis

Alignment Length:	443	Identity:	167/443 - (37%)
Similarity:	249/443 - (56%)	Gaps:	67/443 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 TTLVPLSDTPLLLE-EFAAGEFVL---PPLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRR 195
            ||..|:|.:....| :...||.::   ..:..:.:..:|.::.|.|:.||.||.|:||.|:|||:
Frog    47 TTASPISTSTFSSENDTQCGELMILNYGHIEKLVIGAILSLITLLTIAGNCLVVISVCFVKKLRQ 111

  Fly   196 PCNYLLVSLALSDLCVALLVMPMALLYEVL-EKWNFGPLLCDIWVSFDVLCCTASILNLCAISVD 259
            |.|||:|||||:||.||:.|||...:.::: .:|.||.:.|:::::.||:||||||:.||.||:|
Frog   112 PSNYLIVSLALADLSVAIAVMPFVSVTDLIGGEWIFGHVFCNVFIAMDVMCCTASIMTLCVISID 176

  Fly   260 RYLAITKPLEYGVKRTPR---RMMLCVGIVWLAAACISLPPLLILGNEHEDEEGQPICTVCQNFA 321
            |||.||:||.|.|::..|   :|:||   |||.:|.|:||||........|::   :|.:.|:|.
Frog   177 RYLGITRPLTYPVRQNGRCMAKMILC---VWLLSASITLPPLFGWAQNVNDDK---VCLISQDFG 235

  Fly   322 YQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHTEL 386
            |.||:|..:||||:|||||:||:||:||:|...:.|           .||.|...::..:    :
Frog   236 YTIYSTAVAFYIPMSVMLFMYYRIFKAAKRSAAKHK-----------FTGLPRPEESEGM----I 285

  Fly   387 ASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKK 451
            :::||.:.|..       ...|..||.                   ||.:.......|:  :|:|
Frog   286 SANGNVKTHKE-------SEECTNLSK-------------------LLRNDRKNISIFK--REQK 322

  Fly   452 ASTTLGIIMSAFTVCWLPFFILALIRPF----ETMHVPASLSSLFLWLGYANSLLNPIIYATLNR 512
            |:||||||:.|||:||||||:|:..|||    |...:|..|...||||||||||:||.|||..||
Frog   323 AATTLGIIVGAFTICWLPFFLLSTARPFICGTECSCIPLWLERTFLWLGYANSLINPFIYAFFNR 387

  Fly   513 DFRKPFQEILYFRCSSLNTMMRENYYQD--QYGEPPSQRVMLGDERHGARESF 563
            |.|..::.:|..|..::|..:......:  :..|.|.:.:   ..|| :||.|
Frog   388 DLRTTYRNLLQCRYRNINRKLSAAGMHEALKLAERPDRAL---TRRH-SREHF 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_001263131.1	7tm_4	173..>342	CDD:304433	85/172 (49%)
5-HT7	NP_001263131.1	7tm_1	179..507	CDD:278431	140/335 (42%)
htr7	XP_031762460.1	7tmA_5-HT7	80..393	CDD:320452	150/361 (42%)
		TM helix 1	81..105	CDD:320452	9/23 (39%)
		TM helix 2	114..136	CDD:320452	15/21 (71%)
		TM helix 3	153..175	CDD:320452	11/21 (52%)
		TM helix 4	198..214	CDD:320452	9/18 (50%)
		TM helix 5	234..257	CDD:320452	14/22 (64%)
		TM helix 6	324..346	CDD:320452	16/21 (76%)
		TM helix 7	361..386	CDD:320452	16/24 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	245	1.000	Domainoid score	I2139
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20244
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1327781at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47492
Panther	1	1.100	-	-	LDO	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1464
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.020