Protein Alignment 5-HT7 and LOC100490372

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_002937327.2
• Gene: LOC100490372 / 100490372
• XenbaseID: XB-GENE-29080159
• Length: 405
• Species: Xenopus tropicalis
• Alignment Length: 373
• Identity: 113/373 - (30%)
• Similarity: 179/373 - (47%)
• Gaps: 85/373 - (22%)

  Fly   163 IFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEK 227
            :.|..:|.::.|.|.:||.:|.|...:.::||......::|||::||.||.||||.:::|||...
 Frog    56 VAVGSLLTVIDLITFLGNAVVFICPVVEKRLRTVTYMFIMSLAMADLLVACLVMPFSIIYEVTGM 120

  Fly   228 WNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAAC 292
            |.||...|.:|:||||:.|||||:.||.||:|||.::..|..|..:.:.||.::....:|:.::.
 Frog   121 WLFGKQFCKVWISFDVMFCTASIVTLCFISLDRYCSVVTPYHYSKRMSRRRCIIMTVTIWVYSSL 185

  Fly   293 ISLPPLLILGNE--HEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAAR----R 351
            ||..|::...||  ..|.:....|....|:.:.|.|:..:||||..:|..:|:.|:||:|    |
 Frog   186 ISFLPVMQGWNEIPGVDTDNGKQCIFVTNWTFAIVASSLAFYIPFIIMCSMYFFIYRASRLKATR 250

  Fly   352 IVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSSGGG 416
            ||     :||                      .:|....|.:|.::
 Frog   251 IV-----SQT----------------------LDLHYHPNSKRQNN------------------- 269

  Fly   417 ALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPFE- 480
                                         |..|.||:.|:|||:|.|.:||||:|:|.::...:
 Frog   270 -----------------------------LQLENKATRTMGIIISVFVMCWLPYFVLNVLIAAKG 305

  Fly   481 ---TMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFR 525
               |..|..:......||||.||.:||::||.|||||::..:::|..|
 Frog   306 TDSTSRVLVNAFKFITWLGYCNSTINPMLYAFLNRDFQRALKKLLICR 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	111/364 (30%)
		TM helix 1	164..190	CDD:320452	8/25 (32%)
		TM helix 2	197..223	CDD:320452	11/25 (44%)
		TM helix 3	235..265	CDD:320452	18/29 (62%)
		TM helix 4	277..299	CDD:320452	6/21 (29%)
		TM helix 5	319..348	CDD:320452	10/28 (36%)
		TM helix 6	447..477	CDD:320452	15/29 (52%)
		TM helix 7	486..511	CDD:320452	10/24 (42%)
LOC100490372	XP_002937327.2	7tmA_amine_R-like	58..346	CDD:320098	111/362 (31%)
		TM helix 1	58..83	CDD:320098	8/24 (33%)
		TM helix 2	90..117	CDD:320098	12/26 (46%)
		TM helix 3	128..158	CDD:320098	18/29 (62%)
		TM helix 4	170..190	CDD:320098	5/19 (26%)
		TM helix 5	214..270	CDD:320098	21/130 (16%)
		TM helix 6	271..301	CDD:320098	15/29 (52%)
		TM helix 7	311..339	CDD:320098	11/27 (41%)