Protein Alignment 5-HT7 and LOC100488258

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_012818683.1
• Gene: LOC100488258 / 100488258
• XenbaseID: XB-GENE-29079119
• Length: 333
• Species: Xenopus tropicalis
• Alignment Length: 367
• Identity: 110/367 - (29%)
• Similarity: 157/367 - (42%)
• Gaps: 87/367 - (23%)

  Fly   168 VLLIVILG----TVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKW 228
            |:.|.:.|    |.|||:||.|::...|:|..|.|:|::|||.:|..:.|:|||.:::..:...|
 Frog    24 VMFIAMFGAIILTTVGNLLVIISISHFRQLHYPTNFLILSLATADFLIGLVVMPYSMVRSLTSCW 88

  Fly   229 NFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACI 293
            .||.|.|.:....|:..||.||.:|..||||||.|:..||.|....|...:.|.:...|..:...
 Frog    89 YFGDLFCKVHSCLDMTLCTGSIYHLFFISVDRYYAVCHPLHYYKNLTTNVIELFLLTTWSVSCVF 153

  Fly   294 SLPPLLILGNEHEDEEGQPI--------CTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAAR 350
            |..  |:..|.|.:.....|        |::..|..:...::|..|:||.::|:.:|..||..||
 Frog   154 SFG--LVFSNVHTEGIQDYITSYYCIGSCSLTLNKLWGTISSLICFFIPGALMIGIYMHIFSVAR 216

  Fly   351 RIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSSGG 415
            .   :.|....|                                ||.
 Frog   217 N---QAKLVHNH--------------------------------HSF------------------ 228

  Fly   416 GALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPFE 480
                                .|...|.:..:..|:||:.||.|:|..|..||||||||.:|.|:.
 Frog   229 --------------------QPDKSKSKISVRAERKAAKTLSIVMGVFLFCWLPFFILTVIDPYI 273

  Fly   481 TMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEIL 522
            ...||..|.::||||||.||.|||||||.....|:|.|..|:
 Frog   274 NFSVPEDLYNVFLWLGYFNSALNPIIYALFYPWFQKAFACII 315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	108/361 (30%)
		TM helix 1	164..190	CDD:320452	10/25 (40%)
		TM helix 2	197..223	CDD:320452	10/25 (40%)
		TM helix 3	235..265	CDD:320452	14/29 (48%)
		TM helix 4	277..299	CDD:320452	3/21 (14%)
		TM helix 5	319..348	CDD:320452	9/28 (32%)
		TM helix 6	447..477	CDD:320452	16/29 (55%)
		TM helix 7	486..511	CDD:320452	16/24 (67%)
LOC100488258	XP_012818683.1	7tmA_TAAR2_3_4	23..311	CDD:320437	108/361 (30%)
		TM helix 1	24..50	CDD:320437	10/25 (40%)
		TM helix 2	57..83	CDD:320437	10/25 (40%)
		TM helix 3	95..125	CDD:320437	14/29 (48%)
		TM helix 4	137..160	CDD:320437	4/24 (17%)
		TM helix 5	185..214	CDD:320437	9/28 (32%)
		TM helix 6	240..270	CDD:320437	16/29 (55%)
		TM helix 7	279..304	CDD:320437	16/24 (67%)