Protein Alignment 5-HT7 and drd4

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_002937535.2
• Gene: drd4 / 100486482
• XenbaseID: XB-GENE-990215
• Length: 414
• Species: Xenopus tropicalis
• Alignment Length: 386
• Identity: 122/386 - (31%)
• Similarity: 196/386 - (50%)
• Gaps: 57/386 - (14%)

  Fly   164 FVSIVL-LIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYE-VLE 226
            |:::|. .|:|:..:.||||||::||..:.|:...||.:||||::||.:|:||:|:.:..| |..
 Frog    63 FLALVFGFILIVCIICGNVLVCLSVCTEKALKTTTNYFIVSLAVADLLLAVLVLPLYVYTEFVGG 127

  Fly   227 KWNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAA 291
            .|....:|||:.::.||:.|||||.|||||||||::|::.||.|..::...|.:..:...|:.|.
 Frog   128 VWTLSLVLCDVLMTMDVMLCTASIFNLCAISVDRFIAVSIPLNYNRRQVDNRQLFLISTTWIFAF 192

  Fly   292 CISLPPLLILGNEHEDEEGQPICTVC--QNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVL 354
            .::.|.:..|.|..:.:.     |:|  ::..|.:|:::.||:||..:||.:|..:|...|:  .
 Frog   193 AVASPVIFGLNNVADRDP-----TMCKLEDNNYIVYSSVCSFFIPCPIMLVLYCAMFHGLRK--W 250

  Fly   355 EEKR---AQTHLQQALNGTGSPS-----APQAPPLGHTELASSG----------NGQRHSSVGNT 401
            ||.|   .::|:...|.....|:     :|....|....|...|          ||....:|...
 Frog   251 EETRKTKLRSHMSPGLKPPQCPALLLDRSPTDSKLDELNLYDQGDCPFPKSYVDNGHGIQTVAYP 315

  Fly   402 SLTYSTCGGLSSGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVC 466
            .|.|||                          ...|..|:.:.. .:|:||...|.:::.||..|
 Frog   316 HLKYST--------------------------NMEPERKQAKIN-GRERKAMRVLPVVVGAFLFC 353

  Fly   467 WLPFFILALIRPF-ETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRC 526
            |.|||::.:.|.. |:.::|..|.|:..||||.||.|||:||...|.:||..|:::|...|
 Frog   354 WTPFFVVHITRALCESCYIPEQLISIVTWLGYVNSALNPVIYTIFNTEFRNYFRKVLRVCC 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	119/376 (32%)
		TM helix 1	164..190	CDD:320452	12/26 (46%)
		TM helix 2	197..223	CDD:320452	12/25 (48%)
		TM helix 3	235..265	CDD:320452	19/29 (66%)
		TM helix 4	277..299	CDD:320452	4/21 (19%)
		TM helix 5	319..348	CDD:320452	10/28 (36%)
		TM helix 6	447..477	CDD:320452	11/29 (38%)
		TM helix 7	486..511	CDD:320452	13/24 (54%)
drd4	XP_002937535.2	7tmA_D4_dopamine_R	63..406	CDD:320434	119/376 (32%)
		TM helix 1	64..90	CDD:320434	11/25 (44%)
		TM helix 2	97..123	CDD:320434	12/25 (48%)
		TM helix 3	136..166	CDD:320434	19/29 (66%)
		TM helix 4	178..201	CDD:320434	4/22 (18%)
		TM helix 5	217..246	CDD:320434	10/28 (36%)
		TM helix 6	334..364	CDD:320434	11/29 (38%)
		TM helix 7	374..399	CDD:320434	13/24 (54%)