Protein Alignment 5-HT7 and htr7l

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_031751116.1
• Gene: htr7l / 100486231
• XenbaseID: XB-GENE-22064791
• Length: 425
• Species: Xenopus tropicalis
• Alignment Length: 431
• Identity: 153/431 - (35%)
• Similarity: 225/431 - (52%)
• Gaps: 68/431 - (15%)

  Fly   112 MNSSPIAIVSYQGITSSN---LGDSNTTLVPLSDTPLLLEEFAAGEFVLPPLTSIFVSIVLLIVI 173
            |...|: |.:.|.:|:.|   ..|....::...||                 ..|.:.:||.|:.
 Frog    35 MTERPL-ITTEQNLTTLNHTEKDDCGKEILLYGDT-----------------EKIVIGVVLSIIT 81

  Fly   174 LGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVL-EKWNFGPLLCDI 237
            |.|:.||.||.|:||:|:|||:|.|||:||||.:||.||:.|||..::.::: .:|.||.:.|::
 Frog    82 LFTIAGNALVIISVCIVKKLRQPSNYLVVSLAAADLSVAVAVMPFVIITDLVGGEWLFGKVFCNV 146

  Fly   238 WVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLILG 302
            :::.||:||||||:.||.|||||||.||:||.|..::..:.|...|.||||.:|.|:||||....
 Frog   147 FIAMDVMCCTASIMTLCVISVDRYLGITRPLTYPARQNGKLMAKMVFIVWLLSASITLPPLFGWA 211

  Fly   303 NEHEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEEKRAQTHLQQAL 367
            .....|:   :|.:.|:|.|.:|:|..:||||::|||.:|.:||.||:  :..||....::.:..
 Frog   212 KNVNIEK---VCLISQDFGYTVYSTAVAFYIPMTVMLIMYQRIFVAAK--ISAEKHKFVNIPRLY 271

  Fly   368 NGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTG 432
            ...|.....:       :|....|.:::.:|..    ::|...|..
 Frog   272 EQEGIYCLEE-------KLPPKKNSKKNKAVEE----FATLSKLIR------------------- 306

  Fly   433 LLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPF----ETMHVPASLSSLFL 493
                 ..:|......:|:||:.|||||:.|||.||||||:|:..|||    ....:|..|....|
 Frog   307 -----QDRKNISIFKREQKAARTLGIIVGAFTFCWLPFFLLSTARPFICGIMCSCMPLRLERTLL 366

  Fly   494 WLGYANSLLNPIIYATLNRDFRKPFQEILYFRCSSLNTMMR 534
            ||||.|||:||:|||..|||.|..|..:|  ||...|...|
 Frog   367 WLGYTNSLINPLIYAFFNRDLRTTFWNLL--RCKYTNINRR 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	138/359 (38%)
		TM helix 1	164..190	CDD:320452	12/25 (48%)
		TM helix 2	197..223	CDD:320452	14/25 (56%)
		TM helix 3	235..265	CDD:320452	18/29 (62%)
		TM helix 4	277..299	CDD:320452	11/21 (52%)
		TM helix 5	319..348	CDD:320452	14/28 (50%)
		TM helix 6	447..477	CDD:320452	18/29 (62%)
		TM helix 7	486..511	CDD:320452	14/24 (58%)
htr7l	XP_031751116.1	7tmA_5-HT7	71..391	CDD:320452	138/359 (38%)
		TM helix 1	72..98	CDD:320452	12/25 (48%)
		TM helix 2	105..131	CDD:320452	14/25 (56%)
		TM helix 3	144..174	CDD:320452	18/29 (62%)
		TM helix 4	186..208	CDD:320452	11/21 (52%)
		TM helix 5	225..254	CDD:320452	14/28 (50%)
		TM helix 6	316..346	CDD:320452	18/29 (62%)
		TM helix 7	359..384	CDD:320452	14/24 (58%)