Protein Alignment 5-HT7 and hrh2b

DIOPT Version :10

• Sequence 1: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001103208.1
• Gene: hrh2b / 100005590
• ZFINID: ZDB-GENE-070928-20
• Length: 335
• Species: Danio rerio
• Alignment Length: 388
• Identity: 120/388 - (30%)
• Similarity: 178/388 - (45%)
• Gaps: 93/388 - (23%)

  Fly   167 IVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLE-KWNF 230
            :||:..|..|:.||:|||:||...|:|.:..:..::|||::||.:.|||:|::.:.|:.. ||..
Zfish     9 VVLVAFIALTICGNILVCMAVATSRRLHQLSSCFILSLAVTDLLLGLLVLPLSAMLELRNGKWPL 73

  Fly   231 GPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISL 295
            |.:.|:|::|.||:..:||||.|.||||||||||:.||.|..:.||||:.:.:..:|..:..:|.
Zfish    74 GGVFCNIYISMDVMLSSASILTLLAISVDRYLAISNPLFYPRRVTPRRVAIALTAIWTCSLAVSF 138

  Fly   296 PPLLILGNE-------------HEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFR 347
            ..:.:..|.             .|.|||: .|....|..|.:....|.||:||.||..:|::||.
Zfish   139 VSINLGWNSPDFRVQNLDWSMWGEGEEGR-TCRYEWNNNYVLLKAFGIFYLPLLVMCGMYHRIFC 202

  Fly   348 AARRIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLS 412
            .||..|...:.|            :||:.||                    .|.:.|
Zfish   203 VAREQVRRIRAA------------TPSSAQA--------------------ANAAAT-------- 227

  Fly   413 SGGGALAGHGSGGGVSGSTGLLGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIR 477
                                              |:|.||:.||..::.||.:||.|:|......
Zfish   228 ----------------------------------AREHKATVTLAAVLGAFIICWFPYFTYFTYM 258

  Fly   478 PFETMHVPASLSSLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRC---SSLNTMMRENY 537
            ....:|......|:.|||||.||.||||:|..|||||.:...::| .||   ...||..|:.:
Zfish   259 GMWAIHPNKLTHSIVLWLGYLNSALNPILYPALNRDFHQACGQLL-CRCGKKGDFNTSRRKTF 320

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	114/364 (31%)
		TM helix 1	164..190	CDD:320452	11/22 (50%)
		TM helix 2	197..223	CDD:320452	9/25 (36%)
		TM helix 3	235..265	CDD:320452	19/29 (66%)
		TM helix 4	277..299	CDD:320452	4/21 (19%)
		TM helix 5	319..348	CDD:320452	12/28 (43%)
		TM helix 6	447..477	CDD:320452	12/29 (41%)
		TM helix 7	486..511	CDD:320452	13/24 (54%)
hrh2b	NP_001103208.1	7tmA_Histamine_H2R	5..299	CDD:320179	114/364 (31%)
		TM helix 1	6..32	CDD:320179	11/22 (50%)
		TM helix 2	39..66	CDD:320179	9/26 (35%)
		TM helix 3	78..108	CDD:320179	19/29 (66%)
		TM helix 4	120..140	CDD:320179	4/19 (21%)
		TM helix 5	174..204	CDD:320179	12/29 (41%)
		TM helix 6	228..258	CDD:320179	12/29 (41%)
		TM helix 7	267..292	CDD:320179	13/24 (54%)