Protein Alignment 5-HT7 and htr1fa

DIOPT Version :9

• Sequence 1: NP_001263131.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_017213382.1
• Gene: htr1fa / 100005344
• ZFINID: ZDB-GENE-081105-125
• Length: 363
• Species: Danio rerio
• Alignment Length: 422
• Identity: 152/422 - (36%)
• Similarity: 216/422 - (51%)
• Gaps: 66/422 - (15%)

  Fly   111 SMNSSPIAIVSYQGITSSNLGDSNTTLVPLSDTPLLLEEFAAGEFVLPPLTSIFVSIVLLIVILG 175
            |.||:        |:.|::.|.|...                |:.||..||..|::|:
Zfish     2 SSNSA--------GMDSNHTGPSKNN----------------GDVVLLSLTLSFLAIL------- 35

  Fly   176 TVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNFGPLLCDIWVS 240
            |...|.||..|:.:.|||..|.|||:.|||::||.||:||||.:::|...:.|..|..||..|:|
Zfish    36 TTAMNCLVITAIIVTRKLHHPSNYLICSLAVTDLLVAILVMPFSIIYIAKDTWLIGEALCKFWLS 100

  Fly   241 FDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISLPPLLILGNEH 305
            .|:.|||.|||:|.||:||||.|||..:||..|||..|..:.:.:|||.|..|||||:| |.|..
Zfish   101 VDITCCTCSILHLAAIAVDRYRAITDAVEYSRKRTSLRAAIMISVVWLLAIVISLPPIL-LRNGE 164

  Fly   306 EDEEGQPICTVCQ-NFAYQIYATLGSFYIPLSVMLFVYYQIFRAARRIVLEEKRAQTHLQQA-LN 368
            |:|     |.:.. |.|..:|:|.|:|||||.::|.:||:|:|||:  .|..:|..:.|.:: :|
Zfish   165 ENE-----CIIVHTNIASMLYSTFGAFYIPLILILILYYKIYRAAK--TLYHRRRTSCLNKSEMN 222

  Fly   369 GTGSPSAPQAPPLGHTELASSGNGQRHSSVGNTSLTYSTCGGLSSGGGALAGHGSGGGVSGSTGL 433
            |...|......|.....|:.........|.....:..:.....|....:|..|
Zfish   223 GHMLPKCSDREPTTPDTLSPPEKSMSEPSTEGDRVRITARSPKSRRERSLRRH------------ 275

  Fly   434 LGSPHHKKLRFQLAKEKKASTTLGIIMSAFTVCWLPFFILALIRPFETMHVPAS--LSSLFLWLG 496
                     |....:||||:||||:|:.||.||||||||..:|....|:....|  :::...|||
Zfish   276 ---------RISNIREKKAATTLGLIIGAFVVCWLPFFIHEVIYNICTVSCSRSVAVTNFLTWLG 331

  Fly   497 YANSLLNPIIYATLNRDFRKPFQEILYFRCSS 528
            |.|||:||:||...|.||::.||:|:  :|.:
Zfish   332 YLNSLINPLIYTIFNEDFKRAFQKII--KCKN 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT7	NP_001263131.1	7tm_4	173..>342	CDD:304433	79/169 (47%)
		7tm_1	179..507	CDD:278431	128/331 (39%)
htr1fa	XP_017213382.1	7tm_GPCRs	23..354	CDD:333717	140/366 (38%)
		TM helix 1	25..49	CDD:320095	9/30 (30%)
		TM helix 2	58..80	CDD:320095	14/21 (67%)
		TM helix 3	96..118	CDD:320095	12/21 (57%)
		TM helix 4	141..157	CDD:320095	7/15 (47%)
		TM helix 5	175..198	CDD:320095	10/22 (45%)
		TM helix 6	283..308	CDD:320095	18/24 (75%)
		TM helix 7	321..346	CDD:320095	11/24 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910