Protein Alignment Ptx1 and PHOX2B

DIOPT Version :10

• Sequence 1: NP_001138130.2
• Gene: Ptx1 / 43664
• FlyBaseID: FBgn0020912
• Length: 610
• Species: Drosophila melanogaster
• Sequence 2: NP_003915.2
• Gene: PHOX2B / 8929
• HGNCID: 9143
• Length: 314
• Species: Homo sapiens
• Alignment Length: 230
• Identity: 77/230 - (33%)
• Similarity: 106/230 - (46%)
• Gaps: 45/230 - (19%)

  Fly   257 NDKKNKRQRRQRTHFTSQQLQELEHTFSRNRYPDMSTREEIAMWTNLTEARVRVWFKNRRAKWRK 321
            |:|  ::|||.||.|||.||:|||..|:...|||:.||||:|:..:||||||:|||:|||||:||
Human    93 NEK--RKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRK 155

  Fly   322 RERNAMNAAVAAADFKSGFGTQFMQPFADDSLYSSYPYNNWTKVPSPLGTKPFPWPVNPLGSMVA 386
            :||.|..||.||.:..||..:...:.  |:|..:.....:.|..|.|   .|.|.|
Human   156 QERAAAAAAAAAKNGSSGKKSDSSRD--DESKEAKSTDPDSTGGPGP---NPNPTP--------- 206

  Fly   387 GNHHQNSVNCFNTGASGVAVSMNNASMLPGSMGSSLSNTSNVGAVGAPCPYTTPANPYMYRSAAE 451
                    :|...|..|...|...|   ||:.|..       |..|.|           .:..|.
Human   207 --------SCGANGGGGGGPSPAGA---PGAAGPG-------GPGGEP-----------GKGGAA 242

  Fly   452 PCMSSSMSSSIATLRLKAKQHASAGFGSPYSAPSP 486
            ...:::.:::.|.....|...|:||......||.|
Human   243 AAAAAAAAAAAAAAAAAAGGLAAAGGPGQGWAPGP 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptx1	NP_001138130.2	Homeodomain	265..321	CDD:459649	35/55 (64%)
PHOX2B	NP_003915.2	Homeodomain	99..155	CDD:459649	35/55 (64%)
		polyalanine repeat	241..260		2/18 (11%)