Protein Alignment Ptx1 and PHO2

DIOPT Version :10

• Sequence 1: NP_001138130.2
• Gene: Ptx1 / 43664
• FlyBaseID: FBgn0020912
• Length: 610
• Species: Drosophila melanogaster
• Sequence 2: NP_010177.1
• Gene: PHO2 / 851452
• SGDID: S000002264
• Length: 559
• Species: Saccharomyces cerevisiae
• Alignment Length: 551
• Identity: 105/551 - (19%)
• Similarity: 186/551 - (33%)
• Gaps: 172/551 - (31%)

  Fly   184 DFRDSHSSMTAVANSLDSTHLNNFQTSSTSSISNRSRDRKDGNRSVNETTIKTENISSSGHDEPM 248
            :|...|...|..|..||  :|.:.|........::..:::   :......|:|:|:... ||: .
Yeast     4 EFSYDHDFNTHFATDLD--YLQHDQQQQQQQQHDQQHNQQ---QQPQPQPIQTQNLEHD-HDQ-H 61

  Fly   249 TTSGEEPKNDKKNKRQRRQRTHFTSQQLQELEHTFSRNRYPDMSTREEIAMWTNLTEARVRVWFK 313
            |.......|...:..||.:||....:.|..|:..|..|..|.:..|::|:....:.|..||:||:
Yeast    62 TNDMSASSNASDSGPQRPKRTRAKGEALDVLKRKFEINPTPSLVERKKISDLIGMPEKNVRIWFQ 126

  Fly   314 NRRAKWRKRERNAMNAAV-------AAADFKSG-------FGTQFMQPFADDSL--YSSYPYN-- 360
            |||||.||::..:....:       .|.|:..|       ..|.....|.|:.|  :...|.|
Yeast   127 NRRAKLRKKQHGSNKDTIPSSQSRDIANDYDRGSTDNNLVTTTSTSSIFHDEDLTFFDRIPLNSN 191

  Fly   361 --------------NWTKVPS-PLGTKPF----------PWPVNPLGS-----MVAGNHHQNSVN 395
                          :|.::.| .|..:.|          |..:|.:.|     ||..:...:.:|
Yeast   192 NNYYFFDICSITVGSWNRMKSGALQRRNFQSIKELRNLSPIKINNIMSNATDLMVLISKKNSEIN 256

  Fly   396 CFNTGASGVAVSMNNASML-----PGSMGSSLSNTSNVGAVGAPCPYTTPANPYMYRSAAEPCMS 455
            .|      .:...||..:|     |      ||:.:|       |..|...:..:..|......:
Yeast   257 YF------FSAMANNTKILFRIFFP------LSSVTN-------CSLTLETDDDIINSNNTSDKN 302

  Fly   456 SSM----------------SSSIATLRLKAKQHASAGFGSPYSAPSPVSRSNSAGLSACQYTGVG 504
            :|.                :||      :.|::|...||   .....|:||.:       :....
Yeast   303 NSNTNNDDDNDDNSNEDNDNSS------EDKRNAKDNFG---ELKLTVTRSPT-------FAVYF 351

  Fly   505 VTDVVXENALGALLNQHQHHLQHFSGGS------VGGSGVPNGMQQHSGNMLHHSNLGLDH---- 559
            :.:...|:   ..||........||.|.      ||||.:|:.::....::...::|.||:
Yeast   352 LNNAPDED---PNLNNQWSICDDFSEGRQVNDAFVGGSNIPHTLKGLQKSLRFMNSLILDYKSSN 413

  Fly   560 --------------------------SDLGLVGGGPSNHQDEG---NHSL-----------EGSN 584
                                      ::.......|:.:.::.   :|.|           :|||
Yeast   414 EILPTINTAIPTAAVPQQNIAPPFLNTNSSATDSNPNTNLEDSLFFDHDLLSSSITNTNNGQGSN 478

  Fly   585 KSPMEA--------PLANSSNNNNNDNDDED 607
            .....:        ....:||||:|.|::|:
Yeast   479 NGRQASKDDTLNLLDTTVNSNNNHNANNEEN 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptx1	NP_001138130.2	Homeodomain	265..321	CDD:459649	20/55 (36%)
PHO2	NP_010177.1	COG5576	53..183	CDD:227863	35/131 (27%)