DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptx1 and PHO2

DIOPT Version :9

Sequence 1:	NP_001138130.2	Gene:	Ptx1 / 43664	FlyBaseID:	FBgn0020912	Length:	610	Species:	Drosophila melanogaster
Sequence 2:	NP_010177.1	Gene:	PHO2 / 851452	SGDID:	S000002264	Length:	559	Species:	Saccharomyces cerevisiae

Alignment Length:	551	Identity:	105/551 - (19%)
Similarity:	186/551 - (33%)	Gaps:	172/551 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 DFRDSHSSMTAVANSLDSTHLNNFQTSSTSSISNRSRDRKDGNRSVNETTIKTENISSSGHDEPM 248
            :|...|...|..|..||  :|.:.|........::..:::   :......|:|:|:... ||: .
Yeast     4 EFSYDHDFNTHFATDLD--YLQHDQQQQQQQQHDQQHNQQ---QQPQPQPIQTQNLEHD-HDQ-H 61

  Fly   249 TTSGEEPKNDKKNKRQRRQRTHFTSQQLQELEHTFSRNRYPDMSTREEIAMWTNLTEARVRVWFK 313
            |.......|...:..||.:||....:.|..|:..|..|..|.:..|::|:....:.|..||:||:
Yeast    62 TNDMSASSNASDSGPQRPKRTRAKGEALDVLKRKFEINPTPSLVERKKISDLIGMPEKNVRIWFQ 126

  Fly   314 NRRAKWRKRERNAMNAAV-------AAADFKSG-------FGTQFMQPFADDSL--YSSYPYN-- 360
            |||||.||::..:....:       .|.|:..|       ..|.....|.|:.|  :...|.|
Yeast   127 NRRAKLRKKQHGSNKDTIPSSQSRDIANDYDRGSTDNNLVTTTSTSSIFHDEDLTFFDRIPLNSN 191

  Fly   361 --------------NWTKVPS-PLGTKPF----------PWPVNPLGS-----MVAGNHHQNSVN 395
                          :|.::.| .|..:.|          |..:|.:.|     ||..:...:.:|
Yeast   192 NNYYFFDICSITVGSWNRMKSGALQRRNFQSIKELRNLSPIKINNIMSNATDLMVLISKKNSEIN 256

  Fly   396 CFNTGASGVAVSMNNASML-----PGSMGSSLSNTSNVGAVGAPCPYTTPANPYMYRSAAEPCMS 455
            .|      .:...||..:|     |      ||:.:|       |..|...:..:..|......:
Yeast   257 YF------FSAMANNTKILFRIFFP------LSSVTN-------CSLTLETDDDIINSNNTSDKN 302

  Fly   456 SSM----------------SSSIATLRLKAKQHASAGFGSPYSAPSPVSRSNSAGLSACQYTGVG 504
            :|.                :||      :.|::|...||   .....|:||.:       :....
Yeast   303 NSNTNNDDDNDDNSNEDNDNSS------EDKRNAKDNFG---ELKLTVTRSPT-------FAVYF 351

  Fly   505 VTDVVXENALGALLNQHQHHLQHFSGGS------VGGSGVPNGMQQHSGNMLHHSNLGLDH---- 559
            :.:...|:   ..||........||.|.      ||||.:|:.::....::...::|.||:
Yeast   352 LNNAPDED---PNLNNQWSICDDFSEGRQVNDAFVGGSNIPHTLKGLQKSLRFMNSLILDYKSSN 413

  Fly   560 --------------------------SDLGLVGGGPSNHQDEG---NHSL-----------EGSN 584
                                      ::.......|:.:.::.   :|.|           :|||
Yeast   414 EILPTINTAIPTAAVPQQNIAPPFLNTNSSATDSNPNTNLEDSLFFDHDLLSSSITNTNNGQGSN 478

  Fly   585 KSPMEA--------PLANSSNNNNNDNDDED 607
            .....:        ....:||||:|.|::|:
Yeast   479 NGRQASKDDTLNLLDTTVNSNNNHNANNEEN 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptx1	NP_001138130.2	Homeobox	268..320	CDD:278475	19/51 (37%)
PHO2	NP_010177.1	COG5576	53..183	CDD:227863	35/131 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X469
TreeFam	0	0.000	Not matched by this tool.
	2	1.910