Protein Alignment Ptx1 and SHOX2

DIOPT Version :10

• Sequence 1: NP_001138130.2
• Gene: Ptx1 / 43664
• FlyBaseID: FBgn0020912
• Length: 610
• Species: Drosophila melanogaster
• Sequence 2: NP_003021.3
• Gene: SHOX2 / 6474
• HGNCID: 10854
• Length: 355
• Species: Homo sapiens
• Alignment Length: 504
• Identity: 121/504 - (24%)
• Similarity: 156/504 - (30%)
• Gaps: 231/504 - (45%)

  Fly     2 DRSS----AVGGCGGGGGLGVGVVTSSATALGPGGLTNGGGGVVSGALNGLEAMSAESTGLCLQD 62
            ||||    |.||.|||||.|           |.||   |||||..|
Human    50 DRSSPAVRAAGGGGGGGGGG-----------GGGG---GGGGVGGG------------------- 81

  Fly    63 LVSAGTANGAGSAGSAESATTTSTALSSGSTGSSTVNGGGSSTSGTEHLHSHHSLHDSSSSVSIS 127
                |...|||...|.........|..|...||..:..|....:..|
Human    82 ----GAGGGAGGGRSPVRELDMGAAERSREPGSPRLTEGRRKPTKAE------------------ 124

  Fly   128 PAISSLMPISSLSHLHHSAGQDLVGGYSQHPHHTVVPPHTPKHEPLEKLRIWAETGDFRDSHSSM 192
            ...:.|:|..:...|
Human   125 VQATLLLPGEAFRFL-------------------------------------------------- 139

  Fly   193 TAVANSLDSTHLNNFQTSSTSSISNRSRDRKDGNRSVNETTIKTENISSSGHDEPMTTSGEEPKN 257
                                  :|...:|||:                        ...|.|.:.
Human   140 ----------------------VSPELKDRKE------------------------DAKGMEDEG 158

  Fly   258 DKKNKRQRRQRTHFTSQQLQELEHTFSRNRYPDMSTREEIAMWTNLTEARVRVWFKNRRAKWRKR 322
            ..|.| |||.||:||.:||.|||..|....|||...|||::....|:||||:|||:|||||.||:
Human   159 QTKIK-QRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQ 222

  Fly   323 ERNAMNAAV---AAADFKS-------GFGTQFMQPFADDSLYSSYPYNNWTKVPSPLGTKPFPWP 377
            | |.::..|   ||:.|::       ..|...| ||..||..:..|.:  .:|.:.|
Human   223 E-NQLHKGVLIGAASQFEACRVAPYVNVGALRM-PFQQDSHCNVTPLS--FQVQAQL-------- 275

  Fly   378 VNPLGSMVAGNHHQNSVNCFNTGASGVAVSMNNASMLPGSMGSSLSNTSNVGAVGAPCPYTT-PA 441
              .|.|.||..||....:                                   :.|..||.. ||
Human   276 --QLDSAVAHAHHHLHPH-----------------------------------LAAHAPYMMFPA 303

  Fly   442 NPY---------------MYRSAAEPCMSSSMSSSIATLRLKAKQHASA 475
            .|:               ...:||....::|.:||||.||||||:||:|
Human   304 PPFGLPLATLAADSASAASVVAAAAAAKTTSKNSSIADLRLKAKKHAAA 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptx1	NP_001138130.2	Homeodomain	265..321	CDD:459649	31/55 (56%)
SHOX2	NP_003021.3	Homeodomain	165..221	CDD:459649	31/55 (56%)
		OAR	335..351	CDD:461067	11/15 (73%)