Protein Alignment Ptx1 and PITX3

DIOPT Version :10

• Sequence 1: NP_001138130.2
• Gene: Ptx1 / 43664
• FlyBaseID: FBgn0020912
• Length: 610
• Species: Drosophila melanogaster
• Sequence 2: NP_005020.1
• Gene: PITX3 / 5309
• HGNCID: 9006
• Length: 302
• Species: Homo sapiens
• Alignment Length: 278
• Identity: 120/278 - (43%)
• Similarity: 154/278 - (55%)
• Gaps: 60/278 - (21%)

  Fly   252 GEEPKNDKKNKRQRRQRTHFTSQQLQELEHTFSRNRYPDMSTREEIAMWTNLTEARVRVWFKNRR 316
            |..|::....|:|||||||||||||||||.||.||||||||||||||:|||||||||||||||||
Human    50 GGSPEDGSLKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRR 114

  Fly   317 AKWRKRERNAMNAAVAAADFKSGFGTQFMQPFADDSLYSSYPYNNW--TKVPSPLGTKPFPWPVN 379
            |||||||| :..|.:....|.:..| ..:.|:  :.:|..|.|.||  ..:..||..|.||:..|
Human   115 AKWRKRER-SQQAELCKGSFAAPLG-GLVPPY--EEVYPGYSYGNWPPKALAPPLAAKTFPFAFN 175

  Fly   380 -----PLGSMVAGNHHQNSVNCFNTGASGVAVSMNNASMLPGSM--------------GSSLSNT 425
                 ||.|...          |:..:|..|..:.:|:..||::              |.:.:..
Human   176 SVNVGPLASQPV----------FSPPSSIAASMVPSAAAAPGTVPGPGALQGLGGGPPGLAPAAV 230

  Fly   426 SNVGAVGAPCPYTTPA--------NPYMYRSAAEPCMSSSMSSSIATLRLKAKQHASAGFGSPYS 482
            |: |||.  |||.:.|        :||:||   :||     :||:|:||||||||||..:.:.:.
Human   231 SS-GAVS--CPYASAAAAAAAAASSPYVYR---DPC-----NSSLASLRLKAKQHASFSYPAVHG 284

  Fly   483 APSPVSRSNSAGLSACQY 500
            .|.      :|.||.|||
Human   285 PPP------AANLSPCQY 296

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptx1	NP_001138130.2	Homeodomain	265..321	CDD:459649	52/55 (95%)
PITX3	NP_005020.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		11/20 (55%)
		Homeodomain	63..119	CDD:459649	52/55 (95%)
		OAR	258..275	CDD:461067	12/21 (57%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	262..275		10/12 (83%)
		Nuclear localization signal. /evidence=ECO:0000255	268..272		3/3 (100%)