Protein Alignment Ptx1 and PITX2

DIOPT Version :9

• Sequence 1: NP_001138130.2
• Gene: Ptx1 / 43664
• FlyBaseID: FBgn0020912
• Length: 610
• Species: Drosophila melanogaster
• Sequence 2: NP_000316.2
• Gene: PITX2 / 5308
• HGNCID: 9005
• Length: 324
• Species: Homo sapiens
• Alignment Length: 387
• Identity: 161/387 - (41%)
• Similarity: 197/387 - (50%)
• Gaps: 104/387 - (26%)

  Fly   141 HL-HHSAGQDLVGGYSQHPHH-------TVVPPHTPKHEPLEKLRIWAETGDFRDSHSSMTAVAN 197
            || |.:||..|....|...||       :|:.|..|:
Human     9 HLEHRAAGTKLSAVSSSSCHHPQPLAMASVLAPGQPR---------------------------- 45

  Fly   198 SLDST--HLNNFQTSSTSSISNRSRDRKDGNRSVNETTIKTENISSSGHDEPMTTSGEEPKNDKK 260
            ||||:  .|.....|.|||.....:|:                 |..|.:|.:  ..|:|   .|
Human    46 SLDSSKHRLEVHTISDTSSPEAAEKDK-----------------SQQGKNEDV--GAEDP---SK 88

  Fly   261 NKRQRRQRTHFTSQQLQELEHTFSRNRYPDMSTREEIAMWTNLTEARVRVWFKNRRAKWRKRERN 325
            .|||||||||||||||||||.||.||||||||||||||:||||||||||||||||||||||||||
Human    89 KKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERN 153

  Fly   326 AMNAAVAAADFKSGFGTQF---MQPFADDSLYSSYPYNNWTK---VPSPLGTKPFPW----PVNP 380
            ..     |...|:|||.||   |||:  |.:|..|.||||..   ..:.|.||.||:    .|||
Human   154 QQ-----AELCKNGFGPQFNGLMQPY--DDMYPGYSYNNWAAKGLTSASLSTKSFPFFNSMNVNP 211

  Fly   381 LGSMVAGNHHQNSVNCFNTGASGVAVSMNNASMLPGSMGSSLSNTSNV------GAVGAP-CPYT 438
            |.|....: ..||::..:..:|.|..::..   :|||..:||:|.:|:      .||..| |||.
Human   212 LSSQSMFS-PPNSISSMSMSSSMVPSAVTG---VPGSSLNSLNNLNNLSSPSLNSAVPTPACPYA 272

  Fly   439 TPANPYMYRSAAEPCMSSSMSSSIATLRLKAKQHASAGFGSPYSAPSPVSRSNSAGLSACQY 500
            .|..||:||   :.|     :||:|:||||||||:|.|:.   |..:|.|     .||||||
Human   273 PPTPPYVYR---DTC-----NSSLASLRLKAKQHSSFGYA---SVQNPAS-----NLSACQY 318

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptx1	NP_001138130.2	Homeobox	268..320	CDD:278475	48/51 (94%)
PITX2	NP_000316.2	COG5576	40..>149	CDD:227863	73/158 (46%)
		Homeobox	96..149	CDD:365835	49/52 (94%)
		OAR	282..299	CDD:367680	11/21 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5957
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55454
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3670
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1432356at2759
OrthoFinder	1	1.000	-	-		FOG0001767
OrthoInspector	1	1.000	-	-		otm40595
orthoMCL	1	0.900	-	-		OOG6_107540
Panther	1	1.100	-	-	O	PTHR45882
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3409
SonicParanoid	1	1.000	-	-		X469
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	12.000