DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptx1 and PITX1

DIOPT Version :9

Sequence 1:	NP_001138130.2	Gene:	Ptx1 / 43664	FlyBaseID:	FBgn0020912	Length:	610	Species:	Drosophila melanogaster
Sequence 2:	NP_002644.4	Gene:	PITX1 / 5307	HGNCID:	9004	Length:	314	Species:	Homo sapiens

Alignment Length:	308	Identity:	136/308 - (44%)
Similarity:	173/308 - (56%)	Gaps:	83/308 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 ENISSSGHDE--PMTTSGEEPKNDK----------------KNKRQRRQRTHFTSQQLQELEHTF 283
            ||.:|...|.  |....|.|||..:                |.|:|||||||||||||||||.||
Human    44 ENSASESSDTELPEKERGGEPKGPEDSGAGGTGCGGADDPAKKKKQRRQRTHFTSQQLQELEATF 108

  Fly   284 SRNRYPDMSTREEIAMWTNLTEARVRVWFKNRRAKWRKRERNAMNAAVAAADF-KSGFGTQF--- 344
            .||||||||.|||||:||||||.|||||||||||||||||||..      .|. |.|:..||
Human   109 QRNRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWRKRERNQQ------LDLCKGGYVPQFSGL 167

  Fly   345 MQPFADDSLYSS-YPYNNW---TKVPSPLGTKPFPW--PVNPLGSMVAGNHHQNSVNCFNTGASG 403
            :||:.|  :|:: |.||||   :..|:||.||.|.:  .::||.|.          :.|:..:|.
Human   168 VQPYED--VYAAGYSYNNWAAKSLAPAPLSTKSFTFFNSMSPLSSQ----------SMFSAPSSI 220

  Fly   404 VAVSMNNASMLPGSM---------------GSSLSNTSNVGAVGAPCPYTTPANPY-MYRSAAEP 452
            .:::| .:||.||::               ||||::..:.||    |||.|||:|| :||   :.
Human   221 SSMTM-PSSMGPGAVPGMPNSGLNNINNLTGSSLNSAMSPGA----CPYGTPASPYSVYR---DT 277

  Fly   453 CMSSSMSSSIATLRLKAKQHASAGFGSPYSAPSPVSRSNSAGLSACQY 500
            |     :||:|:||||:|||:|.|:|   ....|.|     ||:||||
Human   278 C-----NSSLASLRLKSKQHSSFGYG---GLQGPAS-----GLNACQY 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptx1	NP_001138130.2	Homeobox	268..320	CDD:278475	46/51 (90%)
PITX1	NP_002644.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..103		24/58 (41%)
		COG5576	36..>146	CDD:227863	62/101 (61%)
		Homeobox	93..146	CDD:395001	47/52 (90%)
		Interaction with PIT-1. /evidence=ECO:0000250	147..279		51/162 (31%)
		OAR	276..293	CDD:397759	10/21 (48%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	280..293		9/12 (75%)
		Nuclear localization signal. /evidence=ECO:0000255	286..290		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5957
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3670
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1432356at2759
OrthoFinder	1	1.000	-	-		FOG0001767
OrthoInspector	1	1.000	-	-		otm40595
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45882
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X469
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	9.070