Protein Alignment Ptx1 and PAX5

DIOPT Version :10

• Sequence 1: NP_001138130.2
• Gene: Ptx1 / 43664
• FlyBaseID: FBgn0020912
• Length: 610
• Species: Drosophila melanogaster
• Sequence 2: NP_057953.1
• Gene: PAX5 / 5079
• HGNCID: 8619
• Length: 391
• Species: Homo sapiens
• Alignment Length: 308
• Identity: 73/308 - (23%)
• Similarity: 108/308 - (35%)
• Gaps: 113/308 - (36%)

  Fly   188 SHS-----SMTAVAN-SLDSTHLNNFQTSSTSSISNRSRDRKDGNRSVNETTIKTENISSSGHDE 246
            |||     |:|.|:: |.||.. :::..|....|::.|.|.....|.        |.|..|
Human   155 SHSIVSTGSVTQVSSVSTDSAG-SSYSISGILGITSPSADTNKRKRD--------EGIQES---- 206

  Fly   247 PMTTSGEEPKNDKKNKRQRRQRTHFTSQQLQELEHTFSRNRYPDM-STREEIAMWTNLTEARVRV 310
            |:......|..|...|:.|...  ||.|||:.|:..|.|..|.|: :|.|.|
Human   207 PVPNGHSLPGRDFLRKQMRGDL--FTQQQLEVLDRVFERQHYSDIFTTTEPI------------- 256

  Fly   311 WFKNRRAKWRKRERNAMNAAVAAA-----DFKSGFGTQFMQPFADDSLYSSYPYNNWTKVPSPLG 370
                      |.|:....:|:|:.     |.|:             :|.|..|.:..:.||.|..
Human   257 ----------KPEQTTEYSAMASLAGGLDDMKA-------------NLASPTPADIGSSVPGPQS 298

  Fly   371 ------------TKP-FPWPVNPLGSMVAGNHHQNSVNCFNTGASGVAVSMNNASMLPGS--MGS 420
                        |.| :|..|.|.|.   |::...::    ||            |:|||  .||
Human   299 YPIVTGRDLASTTLPGYPPHVPPAGQ---GSYSAPTL----TG------------MVPGSEFSGS 344

  Fly   421 SLSNTS-----------NVGAVGAPCPYTTPANPYMYRSAAEPCMSSS 457
            ..|:..           |.|.:|:|..|:..|     |.||.|..:::
Human   345 PYSHPQYSSYNDSWRFPNPGLLGSPYYYSAAA-----RGAAPPAAATA 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptx1	NP_001138130.2	Homeodomain	265..321	CDD:459649	14/56 (25%)
PAX5	NP_057953.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		PAX	16..140	CDD:128645
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	19..75
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	94..142
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..218		10/47 (21%)
		Pax2_C	279..390	CDD:463563	32/146 (22%)